Fission-Fueled Nucleoid Dispersion, a Novel Mitochondrial Metabolic Activation Mechanism

Local regulation of the mitochondrial DNA (mtDNA) transcription within the mitochondria contributes to regulate the respiratory activity by sensing the nucleoid distribution. This is a new regulatory respiratory function within the mitochondria. Moreover, the coordination of mitochondrial fission an...

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Bibliographic Details
Published in:Molecules and cells 2023, 46(5), , pp.278-280
Main Author: Kim, Jeongah
Format: Article
Language:English
Subjects:
Activation, Metabolic
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Mitochondria - metabolism
Mitochondrial Dynamics - physiology
Mitochondrial Proteins - metabolism
생물학
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Summary:Local regulation of the mitochondrial DNA (mtDNA) transcription within the mitochondria contributes to regulate the respiratory activity by sensing the nucleoid distribution. This is a new regulatory respiratory function within the mitochondria. Moreover, the coordination of mitochondrial fission and nucleoid trafficking, mediated by dynamin-related protein 1 (Drp1) and ATPase family AAA domain-containing protein 3A (ATAD3A), regulates the nucleoid distribution. However, defects in the Drp1-mediated fission results in low electron transport chain (ETC) formation due to the low transcription of the mtDNA, while the ATAD3A-mediated nucleoid dispersion led to high ETC formation due to the high transcription of the mtDNA. Additionally, the Drp1-MFF-ATAD3A-nucleoid cascade mediates the communication between the cytosolic mitochondrial fission and mitochondrial matrix nucleoid function. MFF, mitochondrial fission factor. KCI Citation Count: 0
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2023.0043