Tannic acid-mediated native fucoidan coating on Ti/TiO2 surfaces for antiplatelet applications

Antiplatelet surface coating is of importance in biomedical applications of implants because platelet adhesion on the implant surface can cause serious problems such as blood clot formation. Various materials have been synthesized and employed for introducing antiplatelet property on solid surfaces....

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Bibliographic Details
Published in:Macromolecular research 2023, 31(7), , pp.733-737
Main Authors: Jeong, Yeonwoo, Kim, Inho, Kim, Min, Cho, Woo Kyung, Kang, Sung Min
Format: Article
Language:English
Subjects:
Acids
Adhesion
Biomedical materials
Catechol
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Coordination compounds
Crosslinking
High resistance
Nanochemistry
Nanotechnology
Physical Chemistry
Platelets
Polymer Sciences
Polysaccharides
Protective coatings
Soft and Granular Matter
Solid surfaces
Surgical implants
Tannic acid
Titanium
Titanium dioxide
Transplants & implants
고분자공학
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Summary:Antiplatelet surface coating is of importance in biomedical applications of implants because platelet adhesion on the implant surface can cause serious problems such as blood clot formation. Various materials have been synthesized and employed for introducing antiplatelet property on solid surfaces. Recently, marine-derived sulfated polysaccharide fucoidan was emerged as an antiplatelet coating material, because of its high resistance to platelet adhesion and abundance in nature. However, previous studies for fucoidan coating were mainly conducted using catechol-conjugated fucoidan because native fucoidan is not adherent to solid surfaces. This study aims to prepare antiplatelet surface coatings with native fucoidan. Solid surfaces are precoated with tannic acid/metal complexes. The native fucoidan is then grafted on the tannic acid-coated surface through metal-mediated crosslinking reactions. The native fucoidan coating can suppress platelet adhesion on titanium/titanium dioxide surfaces by 97%. Graphical abstract A sustainable approach to antiplatelet surface coating is developed using a natural polysaccharide fucoidan. Solid surfaces are precoated with natural polyphenol tannic acid. Native fucoidan is then grafted on the tannic acid-coated surface by coordination bond formation. The fucoidan-coated solid surfaces effectively suppress platelet adhesions.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-023-00150-9