The ways for ginsenoside Rh2 to fi ght against cancer: the molecular evidences in vitro and in vivo

Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternativesfor therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2(GRh...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ginseng research 2023, 47(2), , pp.173-182
Main Authors: Qi-rui Hu, Yao Pan, Han-cheng Wu, Zhen-zhen Dai, Qing-xin Huang, Ting Luo, Jing Li, Ze-yuan Deng, Fang Chen
Format: Article
Language:English
Subjects:
기타의약학
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 182
container_issue
container_start_page 173
container_title Journal of ginseng research
container_volume
creator Qi-rui Hu
Yao Pan
Han-cheng Wu
Zhen-zhen Dai
Qing-xin Huang
Ting Luo
Jing Li
Ze-yuan Deng
Fang Chen
description Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternativesfor therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2(GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion,and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeuticsto enhance the anticancer effect and reverse the adverse effects. Here we summarized the understandingof the molecular mechanisms underlying the anticancer effects of GRh2 and proposed futuredirections to promote the development and application of GRh2. KCI Citation Count: 0
doi_str_mv 10.1016/j.jgr.2022.09.011
format article
fullrecord <record><control><sourceid>nrf</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10289192</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_kci_go_kr_ARTI_10289192</sourcerecordid><originalsourceid>FETCH-nrf_kci_oai_kci_go_kr_ARTI_102891923</originalsourceid><addsrcrecordid>eNqVi81KxDAURoMoWH8ewN1dC403t7WduBNRdDt0H0ImTdOpCSSx4ttb1Bdwdfg432HsRiAXKLq7mc8ucUIijpKjECesIpRN3cq2P2WVIOrqXXvfnLOLnGfErqe-rZgZJguf-ivDGBM4H7INMfuDhf1EUCKMHtxUQDu9uQJGB2PTA5Qte4-LNR-LTmDXrdhEBh9g9SVF0OHwO9Z4xc5GvWR7_cdLdvvyPDy91iGN6mi8itr_0EV1TOpxP7wpgbSTQlLzr_M3VDVQ5A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The ways for ginsenoside Rh2 to fi ght against cancer: the molecular evidences in vitro and in vivo</title><source>ScienceDirect®</source><source>PubMed Central(OpenAccess)</source><creator>Qi-rui Hu ; Yao Pan ; Han-cheng Wu ; Zhen-zhen Dai ; Qing-xin Huang ; Ting Luo ; Jing Li ; Ze-yuan Deng ; Fang Chen</creator><creatorcontrib>Qi-rui Hu ; Yao Pan ; Han-cheng Wu ; Zhen-zhen Dai ; Qing-xin Huang ; Ting Luo ; Jing Li ; Ze-yuan Deng ; Fang Chen</creatorcontrib><description>Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternativesfor therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2(GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion,and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeuticsto enhance the anticancer effect and reverse the adverse effects. Here we summarized the understandingof the molecular mechanisms underlying the anticancer effects of GRh2 and proposed futuredirections to promote the development and application of GRh2. KCI Citation Count: 0</description><identifier>ISSN: 1226-8453</identifier><identifier>EISSN: 2093-4947</identifier><identifier>DOI: 10.1016/j.jgr.2022.09.011</identifier><language>eng</language><publisher>고려인삼학회</publisher><subject>기타의약학</subject><ispartof>Journal of Ginseng Research, 2023, 47(2), , pp.173-182</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002984866$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi-rui Hu</creatorcontrib><creatorcontrib>Yao Pan</creatorcontrib><creatorcontrib>Han-cheng Wu</creatorcontrib><creatorcontrib>Zhen-zhen Dai</creatorcontrib><creatorcontrib>Qing-xin Huang</creatorcontrib><creatorcontrib>Ting Luo</creatorcontrib><creatorcontrib>Jing Li</creatorcontrib><creatorcontrib>Ze-yuan Deng</creatorcontrib><creatorcontrib>Fang Chen</creatorcontrib><title>The ways for ginsenoside Rh2 to fi ght against cancer: the molecular evidences in vitro and in vivo</title><title>Journal of ginseng research</title><description>Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternativesfor therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2(GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion,and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeuticsto enhance the anticancer effect and reverse the adverse effects. Here we summarized the understandingof the molecular mechanisms underlying the anticancer effects of GRh2 and proposed futuredirections to promote the development and application of GRh2. KCI Citation Count: 0</description><subject>기타의약학</subject><issn>1226-8453</issn><issn>2093-4947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqVi81KxDAURoMoWH8ewN1dC403t7WduBNRdDt0H0ImTdOpCSSx4ttb1Bdwdfg432HsRiAXKLq7mc8ucUIijpKjECesIpRN3cq2P2WVIOrqXXvfnLOLnGfErqe-rZgZJguf-ivDGBM4H7INMfuDhf1EUCKMHtxUQDu9uQJGB2PTA5Qte4-LNR-LTmDXrdhEBh9g9SVF0OHwO9Z4xc5GvWR7_cdLdvvyPDy91iGN6mi8itr_0EV1TOpxP7wpgbSTQlLzr_M3VDVQ5A</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Qi-rui Hu</creator><creator>Yao Pan</creator><creator>Han-cheng Wu</creator><creator>Zhen-zhen Dai</creator><creator>Qing-xin Huang</creator><creator>Ting Luo</creator><creator>Jing Li</creator><creator>Ze-yuan Deng</creator><creator>Fang Chen</creator><general>고려인삼학회</general><scope>ACYCR</scope></search><sort><creationdate>202303</creationdate><title>The ways for ginsenoside Rh2 to fi ght against cancer: the molecular evidences in vitro and in vivo</title><author>Qi-rui Hu ; Yao Pan ; Han-cheng Wu ; Zhen-zhen Dai ; Qing-xin Huang ; Ting Luo ; Jing Li ; Ze-yuan Deng ; Fang Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-nrf_kci_oai_kci_go_kr_ARTI_102891923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>기타의약학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi-rui Hu</creatorcontrib><creatorcontrib>Yao Pan</creatorcontrib><creatorcontrib>Han-cheng Wu</creatorcontrib><creatorcontrib>Zhen-zhen Dai</creatorcontrib><creatorcontrib>Qing-xin Huang</creatorcontrib><creatorcontrib>Ting Luo</creatorcontrib><creatorcontrib>Jing Li</creatorcontrib><creatorcontrib>Ze-yuan Deng</creatorcontrib><creatorcontrib>Fang Chen</creatorcontrib><collection>Korean Citation Index</collection><jtitle>Journal of ginseng research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi-rui Hu</au><au>Yao Pan</au><au>Han-cheng Wu</au><au>Zhen-zhen Dai</au><au>Qing-xin Huang</au><au>Ting Luo</au><au>Jing Li</au><au>Ze-yuan Deng</au><au>Fang Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ways for ginsenoside Rh2 to fi ght against cancer: the molecular evidences in vitro and in vivo</atitle><jtitle>Journal of ginseng research</jtitle><date>2023-03</date><risdate>2023</risdate><spage>173</spage><epage>182</epage><pages>173-182</pages><issn>1226-8453</issn><eissn>2093-4947</eissn><abstract>Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternativesfor therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2(GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion,and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeuticsto enhance the anticancer effect and reverse the adverse effects. Here we summarized the understandingof the molecular mechanisms underlying the anticancer effects of GRh2 and proposed futuredirections to promote the development and application of GRh2. KCI Citation Count: 0</abstract><pub>고려인삼학회</pub><doi>10.1016/j.jgr.2022.09.011</doi></addata></record>
fulltext fulltext
identifier ISSN: 1226-8453
ispartof Journal of Ginseng Research, 2023, 47(2), , pp.173-182
issn 1226-8453
2093-4947
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_10289192
source ScienceDirect®; PubMed Central(OpenAccess)
subjects 기타의약학
title The ways for ginsenoside Rh2 to fi ght against cancer: the molecular evidences in vitro and in vivo
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T00%3A34%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nrf&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20ways%20for%20ginsenoside%20Rh2%20to%20fi%20ght%20against%20cancer:%20the%20molecular%20evidences%20in%20vitro%20and%20in%20vivo&rft.jtitle=Journal%20of%20ginseng%20research&rft.au=Qi-rui%20Hu&rft.date=2023-03&rft.spage=173&rft.epage=182&rft.pages=173-182&rft.issn=1226-8453&rft.eissn=2093-4947&rft_id=info:doi/10.1016/j.jgr.2022.09.011&rft_dat=%3Cnrf%3Eoai_kci_go_kr_ARTI_10289192%3C/nrf%3E%3Cgrp_id%3Ecdi_FETCH-nrf_kci_oai_kci_go_kr_ARTI_102891923%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true