SAPHO 증후군에서 경구 Alendronate로 치료한 1예

• Published in: Journal of rheumatic diseases 2015, 22(5), , pp.313-316
• Main Authors: 심현익, Hyun Ik Shim, 박원, Won Park, 김여주, Yeo Ju Kim, 정경희, Kyong Hee Jung, 백지현, Ji Hyeon Baek, 임미진, Mie Jin Lim, 주고운, Kowoon Joo, 권성렬, Seong Ryul Kwon
• Format: Article
• Language: Korean
• Subjects: Acquired hyperostosis syndrome; Alendronate; Therapeutics; 내과학
• ISSN: 2093-940X; 2233-4718

본 저자들은 손가락의 골절과 감염이 동반된 SAPHO 증후군에서 경구 bisphosphonate로 성공적으로 치료하였기에 이를 보고하는 바이다. SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis is rare compared to other spondyloarthropathies. It is also difficult to diagnose, and treatment methods have not yet been fully identified. Approximately 72% of patients are diagnosed with at least one other disease before a final diagnosis of SAPHO syndrome. In addition, SAPHO syndrome is subject to a delayed diagnosis period of 4.5 to 9.1 years. Medications such as non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and tumor necrosis factor inhibitors are used in treatment of SAPHO syndrome. Bisphosphonate is also used for refractory SAPHO syndrome; however, most reports on this relate to intravenous injection of medication. The authors experienced and subsequently reported on a case involving a patient with SAPHO syndrome accompanied by fracture and infection of the left second finger who was treated with the oral biphosphonate, alendronate. (J Rheum Dis 2015;22:313-316)