Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function

In general, bone homeostasis is maintained through the balance between bone formation and resorption. Disruption in this balance results in bone-related diseases such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Often, enhanced osteoclastogenesis is followed by accelerated bone resorpti...

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Bibliographic Details
Published in:Journal of rheumatic diseases 2016, 23(3), , pp.148-153
Main Authors: Seong, Semun, Kim, Jung Ha, Kim, Nacksung
Format: Article
Language:English
Subjects:
내과학
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Summary:In general, bone homeostasis is maintained through the balance between bone formation and resorption. Disruption in this balance results in bone-related diseases such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Often, enhanced osteoclastogenesis is followed by accelerated bone resorption that is induced by pro-inflammatory cytokines in osteoporosis or rheumatoid arthritis, and leads to bone destruction. In this review study, factors involved in osteoclast differentiation and function are discussed, and how the prevention of such factors is effective in ameliorating bone loss in osteoporosis or rheumatoid arthritis. (J Rheum Dis 2016;23:148-153) KCI Citation Count: 0
ISSN:2093-940X
2233-4718
DOI:10.4078/jrd.2016.23.3.148