The possibility of using dibasic acids as regulators of chitosan transport properties

Recently, a significant number of works have appeared devoted to the creation of materials with controlled delivery of drugs. The most promising polymers for these purposes are polysaccharides, in particular chitosan. Unfortunately, film materials obtained from a solution based on chitosan in salt f...

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Bibliographic Details
Published in:Macromolecular research 2023, 31(9), , pp.863-871
Main Authors: Shurshina, S. Anzhela, Mukhamedyarov, N. Timur, Kuzina, G. Lyudmila, Lazdina, Yu. Mariya, Kulish, I. Elena
Format: Article
Language:English
Subjects:
Acids
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chitosan
Complex Fluids and Microfluidics
Drugs
Nanochemistry
Nanotechnology
Oxalic acid
Photomicrographs
Physical Chemistry
Polymer Sciences
Polymers
Polysaccharides
Sodium sulfate
Soft and Granular Matter
Sorption
Substrates
Succinic acid
Sulfates
Transport properties
Water vapor
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Summary:Recently, a significant number of works have appeared devoted to the creation of materials with controlled delivery of drugs. The most promising polymers for these purposes are polysaccharides, in particular chitosan. Unfortunately, film materials obtained from a solution based on chitosan in salt form are soluble in water. In this regard, the purpose of this work was to consider the possibility of modifying the chitosan film materials. Sodium sulfate, phosphoric, succinic, and oxalic acids were chosen as polymer material modifiers. It was shown that the introduction of sodium sulfate, phosphoric, and oxalic acids leads to the loss of solubility of the film materials, changes of the shape of the sorption curve and decrease in the values of the diffusion coefficients of water vapor occurs. The introduction of a weak dibasic succinic acid as a modifier does not lead to a change in the process of sorption regime. The similar regularities are founded in the study of the process of drug release from the polymer material. Thus, fundamentally possible ways of regulating the transport properties of the chitosan film material with respect to the yield of drugs have been found, which consist in the modification of chitosan with anions of strong polybasic acids. Graphical abstract Micrograph of the surface of a chitosan film in contact with air and a substrate
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-023-00171-4