Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities

Artemongolins A – K ( 1–11 ), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1 , 4 , and 7 were undoubtedl...

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Published in:Archives of pharmacal research 2023, 46(10), , pp.782-794
Main Authors: Shang, Chong, Ma, Yun-Bao, Wang, Yuan, He, Xiao-Feng, Li, Tian-Ze, Chen, Ji-Jun
Format: Article
Language:English
Subjects:
Medicine
Pharmacology/Toxicology
Pharmacy
Research Article
약학
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Summary:Artemongolins A – K ( 1–11 ), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1 , 4 , and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A – K ( 1–11 ) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluation against three human hepatoma cell lines demonstrated that the most active compounds 5 and 6 displayed inhibitory activity with IC 50 values of 88.6 and 57.0 (HepG2), 59.1 and 26.4 (Huh7), and 67.5 and 32.5 (SK-Hep-1) µ M, respectively.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-023-01466-x