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Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats
Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressa...
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Published in: | Journal of ginseng research 2023, 47(4), , pp.552-560 |
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description | Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressant effects of Korean red ginseng water extract (KGE) and its active component in an unpredictable chronic mild stress (UCMS)-induced animal model and elucidate the underlying mechanisms.
The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats.
KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats.
Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.
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doi_str_mv | 10.1016/j.jgr.2023.01.003 |
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The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats.
KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats.
Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.
[Display omitted]</description><identifier>ISSN: 1226-8453</identifier><identifier>EISSN: 2093-4947</identifier><identifier>DOI: 10.1016/j.jgr.2023.01.003</identifier><identifier>PMID: 37397413</identifier><language>eng</language><publisher>Korea (South): Elsevier B.V</publisher><subject>brain-derived neurotrophic factor ; dopamine ; Korean red ginseng water extract ; serotonin ; unpredictable chronic mild stress ; 기타의약학</subject><ispartof>Journal of Ginseng Research, 2023, 47(4), , pp.552-560</ispartof><rights>2023</rights><rights>2023 The Korean Society of Ginseng. Publishing services by Elsevier B.V.</rights><rights>2023 The Korean Society of Ginseng. Publishing services by Elsevier B.V. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-d4fb291fa2d77a84816fddbf21ff2f932ad594591463f3dfdeaba4de8484c32b3</citedby><cites>FETCH-LOGICAL-c583t-d4fb291fa2d77a84816fddbf21ff2f932ad594591463f3dfdeaba4de8484c32b3</cites><orcidid>0000-0003-3206-3826</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310873/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1226845323000039$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37397413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003016126$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Chou, Tzu-wen</creatorcontrib><creatorcontrib>Huang, Huai-Syuan</creatorcontrib><creatorcontrib>Panyod, Suraphan</creatorcontrib><creatorcontrib>Huang, Yun-Ju</creatorcontrib><creatorcontrib>Sheen, Lee-Yan</creatorcontrib><title>Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats</title><title>Journal of ginseng research</title><addtitle>J Ginseng Res</addtitle><description>Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressant effects of Korean red ginseng water extract (KGE) and its active component in an unpredictable chronic mild stress (UCMS)-induced animal model and elucidate the underlying mechanisms.
The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats.
KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats.
Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.
[Display omitted]</description><subject>brain-derived neurotrophic factor</subject><subject>dopamine</subject><subject>Korean red ginseng water extract</subject><subject>serotonin</subject><subject>unpredictable chronic mild stress</subject><subject>기타의약학</subject><issn>1226-8453</issn><issn>2093-4947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9UsuOEzEQHCEQGwIfwAXNBQkhTfBrXuKAVssCEStWQsvZ8tjtxMnEDu2ZAH_BJ-M8iNgL8qEtd1V1q1xZ9pySGSW0erOarRY4Y4TxGaEzQviDbMJIywvRivphNqGMVUUjSn6RPYlxRUhVs1o8zi54zdtaUD7Jfn8OCMrnCCZfOB_BL_IfagDM4eeASg_5FoMZNcRc-cEZ2CLEmK5F79aQg7Wgh5gPSwzjYpk7vwv9ziWRTfBBbZw_EE3eoXK-MIBulyZ5GDEMGLZLp3ObpgRM1BzVEJ9mj6zqIzw71Wn27cP13dWn4ub24_zq8qbQZcOHwgjbsZZaxUxdq0Y0tLLGdJZRa5ltOVOmbEXZUlFxy401oDolDCSk0Jx1fJq9Pup6tHKtnQzKHeoiyDXKy693c0kJZ1XZVgk8P4JNUCu5RbdR-OvAODwEXEiFg9M9yJqbqgZDjWhLQauupbTjpOw4JYyxZPw0e3fU2o7dBowGn3zu74ne73i3TEvt9ttQ0tQ8Kbw6KWD4PkIc5MZFDX2vPIQxStZw1gjO0plm9AjVGGJEsOc5lMh9huRKpgzJfYYkoTJlKHFe_LvgmfE3NAnw8mTdmFpgnDpjvty-v6bJ85bzJuHeHnGQ_nHnAGXUDrxODEypSd65_6zxBxVZ52c</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Chou, Tzu-wen</creator><creator>Huang, Huai-Syuan</creator><creator>Panyod, Suraphan</creator><creator>Huang, Yun-Ju</creator><creator>Sheen, Lee-Yan</creator><general>Elsevier B.V</general><general>고려인삼학회</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>DBRKI</scope><scope>TDB</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0003-3206-3826</orcidid></search><sort><creationdate>20230701</creationdate><title>Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats</title><author>Chou, Tzu-wen ; Huang, Huai-Syuan ; Panyod, Suraphan ; Huang, Yun-Ju ; Sheen, Lee-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-d4fb291fa2d77a84816fddbf21ff2f932ad594591463f3dfdeaba4de8484c32b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>brain-derived neurotrophic factor</topic><topic>dopamine</topic><topic>Korean red ginseng water extract</topic><topic>serotonin</topic><topic>unpredictable chronic mild stress</topic><topic>기타의약학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chou, Tzu-wen</creatorcontrib><creatorcontrib>Huang, Huai-Syuan</creatorcontrib><creatorcontrib>Panyod, Suraphan</creatorcontrib><creatorcontrib>Huang, Yun-Ju</creatorcontrib><creatorcontrib>Sheen, Lee-Yan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>DBPIA - 디비피아</collection><collection>Korean Database (DBpia)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Journal of ginseng research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chou, Tzu-wen</au><au>Huang, Huai-Syuan</au><au>Panyod, Suraphan</au><au>Huang, Yun-Ju</au><au>Sheen, Lee-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats</atitle><jtitle>Journal of ginseng research</jtitle><addtitle>J Ginseng Res</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>47</volume><issue>4</issue><spage>552</spage><epage>560</epage><pages>552-560</pages><issn>1226-8453</issn><eissn>2093-4947</eissn><abstract>Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressant effects of Korean red ginseng water extract (KGE) and its active component in an unpredictable chronic mild stress (UCMS)-induced animal model and elucidate the underlying mechanisms.
The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats.
KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats.
Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.
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subjects | brain-derived neurotrophic factor dopamine Korean red ginseng water extract serotonin unpredictable chronic mild stress 기타의약학 |
title | Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats |
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