Comparison of Helicobacter pylori Eradication Rates Using Standard Triple Therapy and Sequential Therapy

Objectives: The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we us...

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Published in:The Korean journal of helicobacter and upper gastrointestinal research 2023, 23(4), , pp.277-282
Main Authors: Kim, Yuri, Ahn, Ji Yong, Jung, Hwoon-Yong, Noh, Jin Hee, Jung, Kee Wook, Lee, Jeong Hoon, Kim, Do Hoon, Choi, Kee Don, Song, Ho June, Lee, Gin Hyug
Format: Article
Language:English
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내과학
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Summary:Objectives: The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we used a chronological cohort dataset to conduct a comparative analysis of the eradication rates, compliance, and adverse events associated with the 7-day STT and SQ.Methods: A total of 789 patients underwent HPE treatment at Asan Medical Center between July 2013 and August 2017. Among them, 378 received a 7-day STT and 411 received a 10-day SQ. Baseline clinical data and treatment parameters were compared between the two treatment groups.Results: SQ demonstrated an eradication rate of 84.7% (348/411), which was superior to that of the 7-day STT (74.1%; p
ISSN:1738-3331
2671-826X
DOI:10.7704/kjhugr.2023.0042