Antimicrobial curcumin nanoparticles downregulate joint inflammation and improve osteoarthritis

Osteoarthritis (OA) is characterized by degenerative lesions in articular cartilage and becomes increasingly difficult to treat as the inflammatory response progresses and damage to joint cartilage occurs. Therefore, novel therapeutic options are required. In this study, curcumin (Cur) nanoparticles...

Full description

Saved in:
Bibliographic Details
Published in:Macromolecular research 2023, 31(12), , pp.1179-1187
Main Authors: Lin, Zhengqiu, Jiang, Shicui, Ye, Xiuzhi, Dai, Minghai, Yang, Guojing, Liu, Liangle
Format: Article
Language:English
Subjects:
Antibacterial agents
Antiinfectives and antibacterials
Bacterial infections
Bioavailability
Biological effects
Cartilage
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Health aspects
Inflammation
Inflammatory response
Nanochemistry
Nanoparticles
Nanotechnology
Osteoarthritis
Physical Chemistry
Physiological aspects
Polymer Sciences
Soft and Granular Matter
Tannic acid
Zinc compounds
고분자공학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoarthritis (OA) is characterized by degenerative lesions in articular cartilage and becomes increasingly difficult to treat as the inflammatory response progresses and damage to joint cartilage occurs. Therefore, novel therapeutic options are required. In this study, curcumin (Cur) nanoparticles (Cur@Zn&TA) were prepared using a metal–phenol network based on Zn 2+ ions and tannic acid (TA). The poor bioavailability of Cur, caused by low and rapid metabolism, was resolved by metal–phenol network wrapping, thus prolonging the time of action of the drug. This composite nanostructure has several biological effects, including anti-inflammatory, antibacterial, and chondroprotective, which are ideal for treating OA. Animal tests indicated that Cur@Zn&TA nanoparticles can be directly injected into the joint cavity to regulate the inflammatory response of OA, effectively promoting OA repair and preventing bacterial infections to achieve rapid and long-term treatment of OA. Graphical abstract Antimicrobial curcumin nanoparticles were developed to improve osteoarthritis.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-023-00196-9