Controversies in the Hypoxic Uptake Mechanism of Copper(II) diacetyl-di(N4-methylthiosemicarbazone): An Updated Review

Cu(II) diacetyl-di(N4-methylthiosemicarbazone), also known as Cu(II)-ATSM, is a popular copper-complexed thiosemicarbazone derivative that has been widely studied for hypoxia. [64Cu]Cu-ATSM has emerged as an effective tracer for positron emission tomography imaging to functionally characterize hypox...

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Published in:대한방사성의약품학회지, 9(2) 2023, 9(2), , pp.101-105
Main Authors: Thuy Tien Nguyen, Huu Bao Nguyen, 강민경, 유정수
Format: Article
Language:English
Subjects:
방사선과학
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Summary:Cu(II) diacetyl-di(N4-methylthiosemicarbazone), also known as Cu(II)-ATSM, is a popular copper-complexed thiosemicarbazone derivative that has been widely studied for hypoxia. [64Cu]Cu-ATSM has emerged as an effective tracer for positron emission tomography imaging to functionally characterize hypoxic tumors. However, understanding the precise mechanism of cellular uptake and metabolism of Cu(II)-ATSM remains a controversial task in which different hypotheses have been proposed. Herein, we will elucidate the current findings regarding the hypoxic uptake mechanism of Cu(II)-ATSM. Particularly, we will investigate the cell internalization mechanism and intracellular reduction of Cu(II)-ATSM. KCI Citation Count: 0
ISSN:2384-1583
2508-3848