Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53tm1Hw1 with TALEN-mediated Trp53 mutant gene

BACKGROUNDTo evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, cell cycle distribution, apoptotic cell numbers and apoptotic protein expressi...

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Published in:Laboratory animal research 2023, 39(4), , pp.287-297
Main Authors: Yun, Woobin, Kim, Ji Eun, Jin, You Jeong, Roh, Yu Jeong, Song, Hee Jin, Seol, Ayun, Kim, Tae Ryeol, Min, Kyeong Seon, Park, Eun Seo, Park, Gi Ho, Kang, Hyun Gu, Choi, Yeon Shik, Hwang, Dae Youn
Format: Article
Language:English
Subjects:
Ascetic tumor
Chemosensitivity
Doxorubicin
G2 arrest
Solid tumor
Trp53
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Summary:BACKGROUNDTo evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, cell cycle distribution, apoptotic cell numbers and apoptotic protein expression in solid tumor cells and ascetic tumor cells treated with DOX.RESULTSThe primary tumor cells showed a significant (P 
ISSN:2233-7660
1738-6055
2233-7660
DOI:10.1186/s42826-023-00175-2