Association between urinary arsenic concentration and genetic polymorphisms in Korean adults

Arsenic (As) is a human carcinogen widely distributed in the environment. This study evaluated the association between the urinary As concentration and single nucleotide polymorphisms (SNPs) in Korean adults to determine the genetic factors related to As concentration. The study included 496 partici...

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Published in:Toxicological research (Seoul) 2024, 40(1), , pp.179-188
Main Authors: Lee, Seul-Gi, Eom, Sang-Yong, Lim, Ji-Ae, Choi, Byung-Sun, Kwon, Ho-Jang, Hong, Young-Seoub, Kim, Yong-Dae, Kim, Heon, Park, Jung-Duck
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Pharmacology/Toxicology
예방의학
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container_title Toxicological research (Seoul)
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creator Lee, Seul-Gi
Eom, Sang-Yong
Lim, Ji-Ae
Choi, Byung-Sun
Kwon, Ho-Jang
Hong, Young-Seoub
Kim, Yong-Dae
Kim, Heon
Park, Jung-Duck
description Arsenic (As) is a human carcinogen widely distributed in the environment. This study evaluated the association between the urinary As concentration and single nucleotide polymorphisms (SNPs) in Korean adults to determine the genetic factors related to As concentration. The study included 496 participants for the genome-wide association study (GWAS) and 1483 participants for the candidate gene approach study. Participants were 19 years and older. The concentrations of total As (Tot As) and total As metabolites (Tmet As, the sum of inorganic As and their metabolites; arsenite, arsenate, monomethylarsonic, and dimethylarsinic acid) in the urine were analyzed. The GWAS identified four SNPs (rs1432523, rs3776006, rs11171747, and rs807573) associated with urinary Tot As and four SNPs (rs117605537, rs3776006, rs11171747, and rs148103384) significantly associated with urinary Tmet As concentration (P  
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Biomedicine
Original
Original Article
Pharmacology/Toxicology
예방의학
title Association between urinary arsenic concentration and genetic polymorphisms in Korean adults
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