Retrospective Multicenter Analysis of Prognostic Risk Factors for One Year Recurrence in Patient With Renal Cell Carcinoma After Partial or Radical Nephrectomy: Results of Korean Renal Cancer Study Group (KRoCS) Database

• Published in: Journal of Korean medical science 2024, 39(3), , pp.1-9
• Main Authors: Choi, Changil, Kang, Minyong, Seo, Seong Il, Suh, Jungyo, Song, Cheryn, Chung, Jinsoo, Kim, Sung Han, Park, Jae Young, Hwang, Eu Chang, Jeong, Chang Wook, Kwak, Cheol, Kim, Jung Kwon, Hong, Sung-Hoo
• Format: Article
• Language: English
• Subjects: Carcinoma, Renal Cell - surgery; Humans; Kidney Neoplasms - surgery; Middle Aged; Necrosis; Nephrectomy; Original; Prognosis; Republic of Korea; Retrospective Studies; Risk Factors; 의학일반
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2024.39.e11

We sought to identify prognostic risk factors for one year recurrence in patient with renal cell carcinoma (RCC) after partial or radical nephrectomy. We performed a retrospective study of 1,269 patients with RCC after partial or radical nephrectomy and diagnosed recurrence using Korean Renal Cancer Study Group (KRoCS) database between January 1991 and March 2017. Recurrence-free survival (RFS), and overall survival (OS) were calculated using the Kaplan-Meier method and multivariate Cox regression analysis were performed to evaluate independent prognostic factors for recurrence. The median patient age was 56 years and median follow-up period was 67 months. Multivariable analysis demonstrated BMI greater than or equal to 23 and less than 30 (vs. BMI less than 23, hazard ratio [HR]: 0.707, = 0.020) reduced recurrence one year postoperatively. Eastern Cooperative Oncology Group performance status (ECOG PS) greater than or equal to 1 (vs. ECOG PS 0, HR: 1.548, = 0.007), high pathological T stage (pT2 vs. pT1, HR: 2.622, < 0.001; pT3 vs. pT1, HR: 4.256, < 0.001; pT4 vs. pT1, HR: 4.558, < 0.001), and tumor necrosis (vs. no tumor necrosis, HR: 2.822, < 0.001) were independent predictive factors for early recurrence within one year in patients with RCC. Statistically significant differences on RFS and OS were found among pathological T stages (pT2 vs. pT1; pT3 vs. pT1; pT4 vs. pT1, all < 0.001). This large multicenter study demonstrated ECOG PS greater than or equal to 1, high pathological T stage, tumor necrosis and BMI less than 23 were significant prognostic risk factors of early recurrence within one year in patients with RCC who underwent nephrectomy.