The KAAACI Guidelines for Sublingual Immunotherapy

Allergen immunotherapy is regarded as the only disease-modifying treatment option for various allergic conditions, including allergic rhinitis and asthma. Among the routes of administration of allergens, sublingual immunotherapy (SLIT) has gained clinical interest recently, and the prescription of S...

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Published in:Allergy, asthma & immunology research 2024, Asthma & Immunology Research, 16(1), , pp.9-21
Main Authors: Min, Jin-Young, Jee, Hye Mi, Lee, Hwa Young, Kang, Sung-Yoon, Kim, Kyunghoon, Kim, Ju Hee, Park, Kyung Hee, Park, So-Young, Sung, Myongsoon, Lee, Youngsoo, Yang, Eun-Ae, Ryu, Gwanghui, Ha, Eun Kyo, Lee, Sang Min, Lee, Yong Won, Chung, Eun Hee, Choi, Sun Hee, Koh, Young-Il, Kim, Seon Tae, Nahm, Dong-Ho, Park, Jung Won, Shim, Jung Yeon, An, Young Min, Han, Man Yong, Choi, Jeong-Hee, Shin, Yoo Seob, Han, Doo Hee
Format: Article
Language:English
Subjects:
Allergens
Allergic rhinitis
Allergies
Asthma
Effectiveness
Immunology
Immunotherapy
Literature reviews
Oral administration
Otolaryngology
Patients
Pediatrics
Review
Rhinitis
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Summary:Allergen immunotherapy is regarded as the only disease-modifying treatment option for various allergic conditions, including allergic rhinitis and asthma. Among the routes of administration of allergens, sublingual immunotherapy (SLIT) has gained clinical interest recently, and the prescription of SLIT is increasing among patients with allergies. After 30 years of SLIT use, numerous pieces of evidence supporting its efficacy, safety, and mechanism allows SLIT to be considered as an alternative option to subcutaneous immunotherapy. Based on the progressive development of SLIT, the current guideline from the Korean Academy of Asthma, Allergy, and Clinical Immunology aims to provide an expert opinion by allergy, pediatrics, and otorhinolaryngology specialists with an extensive literature review. This guideline addresses the use of SLIT, including 1) mechanisms of action, 2) appropriate patient selection for SLIT, 3) the currently available SLIT products in Korea, and 4) updated information on its efficacy and safety. This guideline will facilitate a better understanding of practical considerations for SLIT.
ISSN:2092-7355
2092-7363
DOI:10.4168/aair.2024.16.1.9