The practice of fecal microbiota transplantation in inflammatory bowel disease

Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the te...

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Bibliographic Details
Published in:Intestinal research 2024, 22(1), , pp.44-64
Main Authors: Arora, Umang, Kedia, Saurabh, Ahuja, Vineet
Format: Article
Language:English
Subjects:
fecal microbiota transplantation
inflammatory bowel diseases
microbiome manipulation therapy
microbiota
Review
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Summary:Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the technical improvement including pretreatment with antibiotics, use of frozen stool samples as well as short donor-to-recipient time are proposed to improve its response rates. Its efficacy in ulcerative colitis has been proven in clinical trials while data is emerging for Crohn’s disease. This review describes briefly the biology behind FMT, the available evidence for its use in IBD, and the host, recipient and procedural factors which determine the clinical outcomes.
ISSN:1598-9100
2288-1956
DOI:10.5217/ir.2023.00085