Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were admi...

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Bibliographic Details
Published in:Food science and biotechnology 2024, 33(4), , pp.969-979
Main Authors: Song, Jae Gwang, Lee, Bomi, Kim, Do Eon, Seo, Bong Kyeong, Oh, Nam Su, Kim, Sae Hun, Kim, Hyung Wook
Format: Article
Language:English
Subjects:
Anticancer properties
antioxidants
Anxiety
brain
Brain damage
Brain injury
Chemistry
Chemistry and Materials Science
Cognitive ability
cognitive disorders
fermentation
Food Science
Impairment
Inflammation
interleukin-6
Intestine
intestines
Memory
memory disorders
Mental depression
mRNA
Nutrition
Research Article
식품과학
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Summary:Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.
ISSN:1226-7708
2092-6456
2092-6456
DOI:10.1007/s10068-023-01387-x