Association between Osteoporosis and Skeletal Muscle Mass in Men

• Published in: Asian spine journal 2024, 18(1), , pp.73-78
• Main Authors: Mizutani, Masaya, Eguchi, Yawara, Toyoguchi, Toru, Orita, Sumihisa, Inage, Kazuhide, Shiga, Yasuhiro, Maki, Satoshi, Nakamura, Junichi, Hagiwara, Shigeo, Aoki, Yasuchika, Inoue, Masahiro, Koda, Masao, Takahashi, Hiroshi, Akazawa, Tsutomu, Ohtori, Seiji
• Format: Article
• Language: English
• Subjects: Clinical Study; male; osteoporosis; skeletal muscle mass; 정형외과학
• ISSN: 1976-1902; 1976-7846
• DOI: 10.31616/asj.2023.0165

Cross-sectional study. This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip strength, and advanced glycation end products (AGEs). Fewer studies have reported the correlation between BMD and skeletal muscle mass in women. Moreover, a few studies have examined the relationship between osteoporosis and skeletal muscle mass. This study included 99 men (mean age, 74.9 years; range, 28-93 years) who visited Qiball Clinic for BMD and body composition examinations. The osteoporosis group consisted of 24 patients (mean age, 72.5 years; range, 44-92 years), and the control group consisted of 75 individuals (mean age, 74.9 years; range, 28-93 years). Whole-body skeletal muscle mass was measured using a bioelectrical impedance analyzer. BMD was measured by dual X-ray absorptiometry. Skin autofluorescence (SAF), a marker of dermal AGE accumulation, was measured using a spectroscope. Osteoporosis was defined as a bone density T score of -2.5 or less. Physical findings, skeletal muscle mass, BMD, grip strength, and SAF were compared between the osteoporosis and control groups. The osteoporosis group had significantly lower trunk muscle mass (23.1 kg vs. 24.9 kg), lower leg muscle mass (14.4 kg vs. 13.0 kg), and skeletal mass index (7.1 kg/m2 vs. 6.7 kg/m2) than the control group (all p