The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

Erectile dysfunction (ED) is considered a microvascular disorder and serves as an indicator for the potential development of cardiovascular disease (CVD). Although left ventricular diastolic dysfunction (LVDD) reflects early myocardial damage caused by microvascular disorders, the association betwee...

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Published in:Investigative and clinical urology 2024, 65(2), , pp.165-172
Main Authors: Hyun, Chang Wan, Hwang, Jae Young, Yun, Seong Woo, Park, Tae Young, Yoon, Sung Goo, Kim, Seung Bin, Noh, Tae Il, Kang, Sung Gu, Kang, Seok Ho, Cho, Dong-Hyuk, Shim, Ji Sung
Format: Article
Language:English
Subjects:
cardiovascular disease
Cardiovascular Diseases - complications
Cross-Sectional Studies
erectile dysfunction
Erectile Dysfunction - complications
Humans
left ventricular diastolic dysfunction
Male
Original
Risk Factors
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - diagnostic imaging
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Summary:Erectile dysfunction (ED) is considered a microvascular disorder and serves as an indicator for the potential development of cardiovascular disease (CVD). Although left ventricular diastolic dysfunction (LVDD) reflects early myocardial damage caused by microvascular disorders, the association between ED and LVDD remains poorly elucidated. A cross-sectional study was conducted on 123 patients with ED. They underwent RigiScan, and conventional echocardiography, and attempted International Index of Erectile Function (IIEF) questionnaire. ED severity was evaluated by measuring changes in the penile base circumference and duration of penile rigidity (≥70%) during erection. The early diastolic velocity of mitral inflow (E) and early diastolic velocity of the mitral annulus (e') were measured using echocardiography. The patients were grouped based on the presence of CVD. Among 123 patients, 29 had CVD and 94 did not. Patients with CVD exhibited more pronounced ED and more severe LVDD. Associations between increased penile circumference with echocardiographic parameters were more prominent in patients with CVD than in those without CVD (ΔTtop and e' wave, r=0.508 and r=0.282, respectively, p for interaction=0.033; ΔTbase and E/e' ratio, r=-0.338 and r=-0.293, respectively, p for interaction
ISSN:2466-0493
2466-054X
2466-054X
DOI:10.4111/icu.20230272