The Long-Term Impact of 5-alpha Reductase Inhibitors on the Development of Bladder Cancer and the Need for Radical Cystectomy: A Nationwide Observational Study

To investigate the long-term effects of taking 5-alpha reductase inhibitors (5ARIs) on the development of bladder cancer (BC) and the implementation of radical cystectomy (RC), a standard procedure for advanced BC. From the National Health Insurance Sharing Service database, males aged over 40 years...

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Bibliographic Details
Published in:The world journal of men's health 2024, 42(2), , pp.460-466
Main Authors: Pyun, Jong Hyun, Son, Nak-Hoon, Ko, Young Hwii, Kim, Sang Won, Kim, Hoseob, Bae, Yoon-Jong
Format: Article
Language:English
Subjects:
5-alpha reductase inhibitors
cystectomy
incidence
Original
urinay bladder neoplasms
비뇨기과학
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Summary:To investigate the long-term effects of taking 5-alpha reductase inhibitors (5ARIs) on the development of bladder cancer (BC) and the implementation of radical cystectomy (RC), a standard procedure for advanced BC. From the National Health Insurance Sharing Service database, males aged over 40 years who underwent serum prostate-specific antigen testing from 2006 through 2017 were identified, which is required for the prescription of 5ARIs. The association between the administration duration of 5ARIs and the practice for BC was analyzed. Of the 3,843,968 subjects, 1,514,713 (39.4%) took 5ARIs for an average of 1.53 years, remaining 2,329,255 (60.6%) as non-5ARI counterparts. The incidence of BC was higher in the non-5ARI than in the 5ARI group (1.25% 0.87%, p
ISSN:2287-4208
2287-4690
DOI:10.5534/wjmh.230137