Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization

[...]Mendelian randomization (MR) serves as a method for causal inference using observational data and single nucleotide polymorphisms as instrumental variables to infer causal relationships. [19] in a recently published paper assessed the causal association between 28 circulating complement compone...

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Published in:Clinical and molecular hepatology 2024, 30(2), , pp.150-153
Main Authors: Rezaee-Zavareh, Mohammad Saeid, Kim, Naomy, Yang, Ju Dong
Format: Article
Language:English
Subjects:
Abdomen
Alcohol
Cancer therapies
Cholangitis
complement system proteins
Conflicts of interest
drug repositioning
Genomes
Hepatitis
hepatocellular carcinoma
Hepatology
Humans
Liver cancer
Liver cirrhosis
Liver Diseases
mendelian randomization
Mendelian Randomization Analysis
Metabolism
Proteins
Roles
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Summary:[...]Mendelian randomization (MR) serves as a method for causal inference using observational data and single nucleotide polymorphisms as instrumental variables to infer causal relationships. [19] in a recently published paper assessed the causal association between 28 circulating complement components and CLDs, including alcohol-related cirrhosis (ALC), MASLD, and three major autoimmune liver diseases, namely AIH, primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and HCC, through two-sample MR. In this study, the authors found a significant association between genetically predicted complement component levels of C1q C chain (C1QC) with AIH, C8 gamma chain (C8G) and complement factor H-related protein 5 (CFHR5) with PSC, CFHR1, CFHR2, and C1QC with ALC, C8G with MASLD, and finally CFHR2, C7, and C15 with HCC using the inverse-variance weighted (IVW) method. [...]future studies should confirm the association using other available GWAS data from other ancestries to confirm the generalizability of the results in a wider population with different ethnic backgrounds. Abbreviations CLD, chronic liver diseases; AIH, autoimmune hepatitis; ALC, alcohol-related cirrhosis; ALD, alcohol-associated liver disease; PSC, primary sclerosing cholangitis; PBC, primary biliary cholangitis; HCC, hepatocellular carcinoma; MASLD, metabolic dysfunction-associated steatotic liver disease; CFHR, complement factor H-related protein; C8G, complement C8 gamma chain; GWAS, genome-wide association study; WM, weighted median; IVW, inverse-variance weighted; MR, mendelian randomization; OR, odds ratio; CI, confidence interval 1.
ISSN:2287-2728
2287-285X
2287-285X
DOI:10.3350/cmh.2024.0116