Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

• Published in: Tuberculosis and respiratory diseases 2024, 87(2), 398, pp.165-175
• Main Authors: Rath, Amit K, Sahu, Dibakar, De, Sajal
• Format: Article
• Language: English
• Subjects: chronic obstructive pulmonary disease; copd assessment test score; expiratory flow limitation at tidal breaths; Original; oscillometry; small airway dysfunction; 내과학
• ISSN: 1738-3536; 2005-6184
• DOI: 10.4046/trd.2023.0139

The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator lung function and respiratory impedance. The severity of COPD and lung function abnormalities were graded according to the GOLD guidelines. SAD was defined as either R5-19 > upper limit of normal and/or X5 < lower limit of normal. The cohort consisted of 95.9% men, with a mean age of 66.3 years. The mean FEV1% predicted and the median CAT scores of the cohort were 56.4% and 14, respectively. The prevalence of post-bronchodilator SAD across GOLD grades one to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-bronchodilator SAD and expiratory flow limitation at tidal breath (EFLT) were 62.8% (95% CI: 56.1-69.9) and 28.1% (95% CI: 21.9-34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p=