The Role of mRNA Quality Control in the Aging of Caenorhabditis elegans

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we review findings regarding the role of mRNA quality control in the aging and longevity of , an outstanding model for aging...

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Bibliographic Details
Published in:Molecules and cells 2023, 46(11), , pp.664-671
Main Authors: Kwon, Hyunwoo C, Bae, Yunkyu, Lee, Seung-Jae V
Format: Article
Language:English
Subjects:
Aging - genetics
Animals
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Humans
Insulin - metabolism
Longevity - genetics
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we review findings regarding the role of mRNA quality control in the aging and longevity of , an outstanding model for aging research. We discuss the recently discovered functions of the proper regulation of nonsense-mediated mRNA decay, ribosome-associated quality control, and mRNA splicing in the aging of . We describe how mRNA quality control contributes to longevity conferred by various regimens, including inhibition of insulin/insulin-like growth factor 1 (IGF-1) signaling, dietary restriction, and reduced mechanistic target of rapamycin signaling. This review provides valuable information regarding the relationship between the mRNA quality control and aging in , which may lead to insights into healthy longevity in complex organisms, including humans.
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2023.0103