Sambou Bamboo salt™ down-regulates the expression levels of angiotensin-converting enzyme 2 in activated human mast cells

• Published in: Food science and biotechnology 2024, 33(7), , pp.1697-1705
• Main Authors: Kang, Ho‑Geun, Choi, Yu‑Jin, Kim, Hee‑Yun, Kim, Hyung‑Min, Jeong, Hyun‑Ja
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; ACE2; Activator protein 1; Angiotensin; Angiotensin-converting enzyme 2; Bamboo; Chemistry; Chemistry and Materials Science; Coronaviruses; COVID-19; Food Science; Inflammation; Inflammatory response; Kinases; Mast cells; Nutrition; Peptidyl-dipeptidase A; Pharmacology; Research Article; Respiratory diseases; Severe acute respiratory syndrome coronavirus 2; Transcription factors; Tryptase; Viral diseases; 식품과학
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-023-01438-3

Mast cells have a detrimental impact on coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Sambou Bamboo salt™ (BS) suppresses mast cell-mediated inflammatory response and enhances immunity. In this study, we investigated the regulatory effects of BS on expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2) in human mast cell line (HMC)-1 cells. BS resulted in significant reductions in expression levels of ACE2 and TMPRSS2 in activated HMC-1 cells. Levels of tryptase were reduced by BS. In addition, BS blocked activation of activator protein 1 (AP-1), c-Jun NH2-terminal kinases (JNK), p38, and phosphatidylinositide-3-kinase (PI3K) in activated HMC-1 cells. Therefore, these results show that BS reduces levels of ACE2, TMPRSS2, and tryptase by inhibiting AP-1/JNK/p38/PI3K signaling pathways in mast cells. These findings can serve as valuable foundational data for the development of therapeutic agents aimed at preventing SARS-CoV-2 infection.