Changes in metabolic syndrome and the risk of breast and endometrial cancer according to menopause in Korean women

This study investigated how changes in metabolic syndrome (MetS) are associated with the subsequent risk of breast and endometrial cancer according to menopausal status. This cohort study, using data from the National Health Insurance Service database, included women aged ≥40 years who underwent 2 b...

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Bibliographic Details
Published in:Epidemiology and health 2023, 45(0), , pp.049-049
Main Authors: Tran, Thi Xuan Mai, Kim, Soyeoun, Park, Boyoung
Format: Article
Language:English
Subjects:
breast neoplasms
early detection of cancer
endometrial neoplasms
metabolic syndrome
obesity
Original
prevention
예방의학
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Summary:This study investigated how changes in metabolic syndrome (MetS) are associated with the subsequent risk of breast and endometrial cancer according to menopausal status. This cohort study, using data from the National Health Insurance Service database, included women aged ≥40 years who underwent 2 biennial cancer screenings (2009-2010 and 2011-2012) and were followed up until 2020. Participants were grouped into MetS-free, MetS-recovery, MetS-development, and MetS-persistent groups. Menopausal status (premenopausal, perimenopausal, and postmenopausal) was assessed at 2 screenings. Cox proportional hazard regression was used to assess the association between MetS changes and cancer risk. In 3,031,980 women, breast and endometrial cancers were detected in 39,184 and 4,298, respectively. Compared with the MetS-free group, those who recovered, developed, or had persistent MetS showed an increased risk of breast cancer, with adjusted hazard ratios (aHRs) of 1.05, 1.05, and 1.11, respectively (p
ISSN:2092-7193
2092-7193
DOI:10.4178/epih.e2023049