Integrative approach in the era of failing drug discovery and development

The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many su...

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Bibliographic Details
Published in:Integrative medicine research 2014, 3(4), 9, pp.211-216
Main Authors: Earm, Keehyun, Earm, Yung E.
Format: Article
Language:English
Subjects:
drug development
integrative
reductionism
Review
systems biology
target-based approach
학제간연구
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Summary:The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many successes, a postreductionism method, which is systems biology, is on the rise. In this review, we discuss the foundations of two distinct approaches in finding a new drug.
ISSN:2213-4220
2213-4239
DOI:10.1016/j.imr.2014.09.002