Gastro-protective effects and anti-Helicobacter pylori activities of the aqueous and methanol extracts of the stem-back of Nauclea pobeguinii (Rubiaceae)

Nauclea pobeguinii ( N. pobeguinii ) is a plant used in African medicine to treat many gastroduodenal diseases. In this study, we determined the gastro-protective mechanisms and anti- Helicobacter pylori ( H. pylori ) properties of N. pobeguinii extracts. Wound healing activity (acetic acid test), a...

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Published in:Advances in traditional medicine (Online) 2024, 24(1), , pp.223-242
Main Authors: Yacine Karelle, Madjo Kouam, Marius, Mbiantcha, Zenab Linda, Fagni Njoya, Vanessa Mba, Matah Marthe, Elvira, Ngoufack Azanze, Eric Gonzal, Tsafack, Stephanie Flore, Djuichou Nguemnang, Carine Flore, Adjouzem, Gilbert, Ateufack
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Pharmacy
Research Article
한의학
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Summary:Nauclea pobeguinii ( N. pobeguinii ) is a plant used in African medicine to treat many gastroduodenal diseases. In this study, we determined the gastro-protective mechanisms and anti- Helicobacter pylori ( H. pylori ) properties of N. pobeguinii extracts. Wound healing activity (acetic acid test), anti-secretory properties (pyloric ligation, pyloric ligation/acetylcholine and pyloric ligation/histamine tests) and cytoprotective effects (ethanol test) were assessed in female rat, the anti- Helicobacter pylori (agar well diffusion method) was also evaluated. At doses of 100, 200 and 400 mg/kg, the extracts reduce ( p  
ISSN:2662-4052
2662-4060
DOI:10.1007/s13596-023-00686-2