Association of IL28B Genotypes and Baseline Serum Interferon-γ-Inducible- Protein-10 Levels with Treatment Response in Hepatitis C Virus Patients in China

• Published in: Gut and liver 2016, 10(3), , pp.446-455
• Main Authors: Zhang, Renwen, Shao, Cuiping, Huo, Na, Li, Minran, Xu, Xiaoyuan
• Format: Article
• Language: English
• Subjects: Antiviral Agents - therapeutic use; Chemokine CXCL10 - metabolism; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - genetics; Humans; il28b; Interferon-alpha - therapeutic use; interferon-γ-inducible-protein-10; Interferons; Interleukins - genetics; Male; Middle Aged; Original; pegylated interferon α-2a plus ribavirin; Polyethylene Glycols - therapeutic use; Polymorphism, Single Nucleotide - genetics; Recombinant Proteins - therapeutic use; Ribavirin - therapeutic use; ROC Curve; Treatment Outcome; viral response; 내과학
• ISSN: 1976-2283; 2005-1212
• DOI: 10.5009/gnl15162

Several studies have demonstrated that serum interferon-γ-inducible-protein-10 (IP-10) levels at baseline and single nucleotide polymorphisms (SNPs) near the IL28B gene were associated with viral response and treatment outcomes. Our purpose was to assess the combination of pretreatment IP-10 levels with IL28B SNPs as predictors of treatment response to pegylated interferon α-2a plus ribavirin in patients infected with genotype 1 hepatitis C virus in China. Seventy-two patients with chronic hepatitis C without fibrosis/cirrhosis were enrolled in the study. The virologic parameters and baseline serum IP-10 levels were determined. IL-28B genotypes were determined by sequencing. In this cohort, serum baseline IP-10 levels lower than 426.7 pg/mL could predict rapid virological response/ sustained virological response (SVR). Patients carrying favorable IL28B SNP genotypes had higher SVRs than did those carrying unfavorable variants (IL28B rs12979860, p=0.002; IL28B rs8099917, p=0.020). Combining both baseline IP- 10 and IL28B SNPs could improve the prediction of SVR in favorable allele carriers of IL28B, rs12979860 CC and rs8099917 TT. Serum baseline IP-10 levels and IL28B genotypes were independent predictors of SVR. Our study shows that the combination of baseline serum IP-10 levels and the determination of IL28B SNPs increase the predictability of SVR rates in this cohort. (Gut Liver 2016;10446-455).