Characteristics of hemorrhagic peptic ulcers in patients receiving antithrombotic/nonsteroidal antiinflammatory drug therapy

Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. We investigated the medical records of 485 consecuti...

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Published in:Gut and liver 2012, 6(4), , pp.423-426
Main Authors: Nakamura, Kazuhiko, Akahoshi, Kazuya, Ochiai, Toshiaki, Komori, Keishi, Haraguchi, Kazuhiro, Tanaka, Munehiro, Nakamura, Norimoto, Tanaka, Yoshimasa, Kakigao, Kana, Ogino, Haruei, Ihara, Eikichi, Akiho, Hirotada, Motomura, Yasuaki, Kabemura, Teppei, Harada, Naohiko, Chijiiwa, Yoshiharu, Ito, Tetsuhide, Takayanagi, Ryoichi
Format: Article
Language:English
Subjects:
anti-inflammatory agents
antithrombotic therapy
endoscopic hemostasis
hemorrhagic ulcer
non-steroidal
Original
peptic ulcer
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Summary:Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. We investigated the medical records of 485 consecutive patients who underwent esophagogastroduodenoscopy and were diagnosed with hemorrhagic gastroduodenal ulcers. The patients treated with antithrombotic agents/NSAIDs were categorized as the antithrombotic therapy (AT) group (n=213). The patients who were not treated with antithrombotics/NSAIDs were categorized as the control (C) group (n=263). The clinical characteristics were compared between the groups. The patients in the AT group were significantly older than those in the C group (p
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl.2012.6.4.423