Expression of DOG1, PDGFRA, and p16 in Gastrointestinal Stromal Tumors

The diagnosis of gastrointestinal stromal tumors (GIST) relies on the demonstration of KIT expression, but KIT expression is absent or reduced in approximately 15% of GIST. Eighty-one GISTs were diagnosed between January 1998 and December 2007 at the Department of Pathology at both Chungnam National...

Full description

Saved in:
Bibliographic Details
Published in:Gut and liver 2011, 5(2), , pp.171-180
Main Authors: Jung, Sung Hee, Suh, Kwang Sun, Kang, Dae Young, Kang, Dong Wook, Kim, Young-Beum, Kim, Eun-Sun
Format: Article
Language:English
Subjects:
dog1
gastrointestinal stromal tumor
mutation
Original
p16
platelet-derived growth factor alpha
내과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The diagnosis of gastrointestinal stromal tumors (GIST) relies on the demonstration of KIT expression, but KIT expression is absent or reduced in approximately 15% of GIST. Eighty-one GISTs were diagnosed between January 1998 and December 2007 at the Department of Pathology at both Chungnam National University Hospital and Eulji University Hospital, Daejeon. Medical history, patient follow-up, and radiographic data were collected if available in the medical records. To determine diagnostic and prognostic markers for GISTs focused on PDGFRA mutation and clinicopathologic features, we analyzed 81 GIST cases for KIT, PDGFRA, DOG1, and p16 expression and for mutation of PDGFRA genes. Among 81 GIST cases, 20 high risk cases (24.7%) were recurred or metastasized. Immunohistochemically, KIT was positive in 76 (93.8%), PDGFRA in 75 (92.7%), and DOG1 in 77 (95.1%). With a cutoff value of 50%, p16 expression was positive in 26 cases were positive (32.1%). A correlation between p16 expression or negative DOG1 expression and recurrence or metastasis was demonstrated (p
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl.2011.5.2.171