Tranexamic acid - a promising hemostatic agent with limitations: a narrative review

Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been used for several decades to reduce blood loss during surgery and after trauma. TXA was traditionally used to reduce bleeding in various clinical settings such as menorrhagia, hemophilia, or other bleeding disorder. Numerous st...

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Bibliographic Details
Published in:Korean journal of anesthesiology 2024, 77(4), , pp.411-422
Main Authors: Kim, Dong Joon, Cho, Su Yeon, Jung, Ki Tae
Format: Article
Language:English
Subjects:
Antifibrinolytic Agents - administration & dosage
Antifibrinolytic Agents - therapeutic use
Blood Loss, Surgical - prevention & control
blood transfusion
cardiac surgical procedures
hemorrhage
Hemostatics - administration & dosage
Hemostatics - therapeutic use
Humans
neurosurgery
orthopedic procedures
postpartum hemorrhage
Review
tranexamic acid
Tranexamic Acid - administration & dosage
Tranexamic Acid - therapeutic use
trauma
마취과학
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Description
Summary:Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been used for several decades to reduce blood loss during surgery and after trauma. TXA was traditionally used to reduce bleeding in various clinical settings such as menorrhagia, hemophilia, or other bleeding disorder. Numerous studies have demonstrated the efficacy of TXA in reducing blood loss and the need for transfusions. Interest in the potential applications of TXA beyond its traditional use has been growing recently, with studies investigating the use of TXA in postpartum hemorrhage, cardiac surgery, trauma, neurosurgery, and orthopedic surgery. Despite its widespread use and expanding indications, data regarding the safe and appropriate use of TXA is lacking. Recent clinical trials have found various potential risks and limitations in the long-term benefits of TXA. This narrative review summarizes the clinical applications and limitations of TXA.
ISSN:2005-6419
2005-7563
2005-7563
DOI:10.4097/kja.23530