Anticarcinogenic potential of the mushroom polysaccharide lentinan on gastric and colon cancer cells: Antiproliferative, antitumorigenic, Mu-2-related death-inducing gene, MUDENG ramifications

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) 2024, 135(0), , pp.122-130
• Main Authors: Park, Gyun Seok, Shin, Juhyun, Hong, Seongwoo, Gopal, Judy, Oh, Jae-Wook
• Format: Article
• Language: English
• Subjects: 화학공학
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2024.01.024

Mushrooms have been known as the elixirs of health, they are well known from ages immemorial for theirnutritional and medicinal properties immunoceutical and immunomodulatory properties. Lentinula edodes(“shiitake”) is a well-accomplished mushroom for its biological and medicinal attributes of huge significance. Lentinan is a bioactive polysaccharide that is extracted from shiitake mushrooms. In the present study, standardcommercially available lentinan polysaccharide was used to demonstrate its anticancer activity. The resultsconfirmed the anti-cancer cell proliferative effect of lentinan on colon and gastric cancer cell lines through theinhibition of G2/M phase in the cell cycle. Lentinan also could attenuate wound healing and colony formationabilities and migration in AGS and HT-29 cells, demonstrating its tumorigenesis potential. Lentinan could increasephospho-p38 and decrease phopho-ERK1/2, Mu-2-related death-inducing gene (MuD) protein. Besides,lentinan also induced reactive oxygen species (ROS) production which was directly involved in cell death. In thisstudy, various aspects of the anticarcinogenic activity of lentinan including the MuD influence have beendemonstrated. This is the first report evidencing cross-talk by lentinan and MuD protein confirming the antiapoptoticfunction of lentinan. KCI Citation Count: 0