Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses

Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors with limited capacity have evolved to third-generation vectors flacking viral coding sequences, balancing safe...

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Bibliographic Details
Published in:The journal of microbiology 2024, 62(7), , pp.491-509
Main Authors: Park, Anyeseu, Lee, Jeong Yoon
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Adenoviruses
Animals
Antiviral agents
Biomedical and Life Sciences
Carrying capacity
CRISPR
CRISPR-Cas Systems
Effectiveness
Expression vectors
Gene editing
Gene Editing - methods
Gene sequencing
Gene therapy
Gene transfer
Gene Transfer Techniques
Genetic modification
Genetic Therapy - methods
Genetic Vectors - genetics
Homologous recombination
Humans
Life Sciences
Microbiology
Minireview
Rare species
Recombination
Therapeutic applications
Vaccine Development
Vaccines
Vectors
생물학
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Summary:Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors with limited capacity have evolved to third-generation vectors flacking viral coding sequences, balancing safety and gene-carrying capacity. The applications of adenoviral vectors for gene therapy and anti-viral treatments have expanded through the use of in vitro ligation and homologous recombination, along with gene editing advancements such as CRISPR-Cas9. Current research aims to maintain the efficacy and safety of adenoviral vectors by addressing challenges such as pre-existing immunity against adenoviral vectors and developing new adenoviral vectors from rare adenovirus types and non-human species. In summary, adenoviral vectors have great potential in gene therapy and vaccine development. Through continuous research and technological advancements, these vectors are expected to lead to the development of safer and more effective treatments.
ISSN:1225-8873
1976-3794
1976-3794
DOI:10.1007/s12275-024-00159-4