Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis

The actin-based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), a member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific dev...

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Published in:Molecules and cells 2024, 47(1), , pp.1-9
Main Authors: Kim, Youni, Lee, Hyun-Kyung, Park, Kyeong-Yeon, Ismail, Tayaba, Lee, Hongchan, Ryu, Hong-Yeoul, Cho, Dong-Hyung, Kwon, Taeg Kyu, Park, Tae Joo, Kwon, Taejoon, Lee, Hyun-Shik
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Cell Movement
Destrin
Destrin - genetics
Destrin - metabolism
Embryonic Development
F-actin
Gene Expression Regulation, Developmental
Neural crest
Neural Crest - cytology
Neural Crest - embryology
Neural Crest - metabolism
Neural Plate - embryology
Neural Plate - metabolism
Neurogenesis
Neurulation
Xenopus laevis
Xenopus laevis - embryology
Xenopus laevis - metabolism
Xenopus Proteins - genetics
Xenopus Proteins - metabolism
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Summary:The actin-based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), a member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific developmental roles of dstn have yet to be fully elucidated. Here, we investigated the physiological functions of dstn during early embryonic development using Xenopus laevis as an experimental model organism. dstn is expressed in anterior neural tissue and neural plate during Xenopus embryogenesis. Depleting dstn promoted morphants with short body axes and small heads. Moreover, dstn inhibition extended the neural plate region, impairing cell migration and distribution during neurulation. In addition to the neural plate, dstn knockdown perturbed neural crest cell migration. Our data suggest new insights for understanding the roles of actin dynamics in embryonic neural development, simultaneously presenting a new challenge for studying the complex networks governing cell migration involving actin dynamics.
ISSN:1016-8478
0219-1032
0219-1032
DOI:10.1016/j.mocell.2024.100076