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The green approach of chitosan/Fe2O3/ZnO-nanocomposite synthesis with an evaluation of its biological activities
Biopolymers embedded with nanoparticles of metal oxides (MOs) demonstrate a wide range of bio-functions. Chitosan-incorporated MOs are an interesting class of support matrices for enhancing the biological function, compared to other support matrices. Therefore, the importance of this study lies in e...
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| Published in: | Applied biological chemistry 2024, 67(0), , pp.1-13 |
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| container_title | Applied biological chemistry |
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| creator | Al-Rajhi, Aisha M. H. Abdelghany, Tarek M. Almuhayawi, Mohammed S. Alruhaili, Mohammed H. Al Jaouni, Soad K. Selim, Samy |
| description | Biopolymers embedded with nanoparticles of metal oxides (MOs) demonstrate a wide range of bio-functions. Chitosan-incorporated MOs are an interesting class of support matrices for enhancing the biological function, compared to other support matrices. Therefore, the importance of this study lies in exploiting chitosan as a carrier not of one metal as in previous studies, but of two metals in the form of a nanocomposite to carry out several biological functions. The coprecipitation approach was employed to synthesize chitosan/Fe
2
O
3
/ZnO-nanocomposite in the present research. The characterization of chitosan/Fe
2
O
3
/ZnO-nanocomposite was performed to find out the morphology and dispersion properties of chitosan/Fe
2
O
3
/ZnO-nanocomposite. The X-ray diffraction (XRD) investigation revealed that these were crystalline. Fourier transforms infrared (FTIR) spectrum bands were viewed at 400/cm and 900/cm, due to the stretching vibration of Fe and Zn oxygen bond. TEM showed that chitosan/Fe
2
O
3
/ZnO-nanocomposite was of 20–95 nm in size. chitosan/Fe
2
O
3
/ZnO-nanocomposite exhibited inhibitory potential against
Staphylococcus aureus
,
Bacillus subtilis, Escherichia coli
, and
Candida albicans
with inhibition zones of 25 ± 0.1, 28 ± 0.2, 27 ± 0.1, and 27 ± 0.2 mm, respectively while didn’t inhibited
Aspergillus niger
. MIC value of nanocomposite was 15.62 ± 0.33 µg/mL for
C. albicans, B. subtilis
and
E. coli
, while it was 62.50 ± 0.66 µg/mL for
Pseudomonas aeruginosa
. Ranged values of nanocomposite MBC (15.62 ± 0.33 to 125 ± 1 µg/mL) were attributed to all tested bacteria. Different concentrations of chitosan/Fe
2
O
3
/ZnO-nanocomposite MBC (25, 50, and 75%) reflected anti-biofilm activity against
E. coli
(85.0, 93.2, and 96.0%),
B. subtilis
(84.88, 92.21, and 96.99%),
S. aureus
81.64, 90.52, and 94.64%) and
P. aurogenosa
(90.11, 94.43, and 98.24%), respectively. The differences in the levels of antimicrobial activities may depend on the type of examined microbes. Antioxidant activity of chitosan/Fe
2
O
3
/ZnO-nanocomposite was recorded with excellent IC
50
values of 16.06 and 32.6 µg/mL using DPPH and ABTS scavenging, respectively. Wound heal by chitosan/Fe
2
O
3
/ZnO-nanocomposite was achieved with 100% compared to the untreated cells (76.75% of wound closer). The cytotoxicity outcomes showed that the IC
50
of the chitosan/Fe
2
O
3
/ZnO-nanocomposite was 564.32 ± 1.46 µg/mL normal WI-38 cells. Based on the achieved findings, the chitosan/Fe
2
O
3
/ZnO-na |
| doi_str_mv | 10.1186/s13765-024-00926-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10621078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_24948e9dbfc64700b719e0dd2fba7bb9</doaj_id><sourcerecordid>3153761218</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-31472fbf768dd56ddec09737379a2fa8672aad3a5e12e3c0c8d82f0debea9d163</originalsourceid><addsrcrecordid>eNp9kk9r3DAQxU1poSHJF-jJ0EspuKs_tiwfQ2jahcBC2V56EWNpbGvjlbaSNiHfvtp1aEsPRYcR4veehplXFO8o-USpFKtIeSuairC6IqRjomKvigtWC1kRWbPXf93fFtcx7gghVEjBGn5RHLYTlmNAdCUcDsGDnko_lHqyyUdwqztkG7764TaVA-e13x98tAnL-OzShNHG8smmqQRX4iPMR0jWu5OBTbHsrZ_9aDXMJehkH22yGK-KNwPMEa9f6mXx_e7z9vZrdb_5sr69ua90XctUcVq3bOiHVkhjGmEMatK1PJ8O2ABStAzAcGiQMuSaaGkkG4jBHqEzVPDL4uPi68KgHrRVHuy5jl49BHXzbbtWlAhGSSszvF5g42GnDsHuITyfFecHH0YFIVk9o2J1V0vsTD9oUbeE9C3tkBiTm4W277vs9WHxytP8ecSY1N5GjfMMDv0xKk6bvC7K6Onb9_-gO38MLo9FcdJJ0uT1tpliC6WDjzHg8LtBStQpAGoJgMoBUOcAKJZFfBHFDLsRwx_r_6h-AZeHs0E</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3098051187</pqid></control><display><type>article</type><title>The green approach of chitosan/Fe2O3/ZnO-nanocomposite synthesis with an evaluation of its biological activities</title><source>Springer Nature Link Journals Open Access</source><source>ProQuest Publicly Available Content Database</source><creator>Al-Rajhi, Aisha M. H. ; Abdelghany, Tarek M. ; Almuhayawi, Mohammed S. ; Alruhaili, Mohammed H. ; Al Jaouni, Soad K. ; Selim, Samy</creator><creatorcontrib>Al-Rajhi, Aisha M. H. ; Abdelghany, Tarek M. ; Almuhayawi, Mohammed S. ; Alruhaili, Mohammed H. ; Al Jaouni, Soad K. ; Selim, Samy</creatorcontrib><description>Biopolymers embedded with nanoparticles of metal oxides (MOs) demonstrate a wide range of bio-functions. Chitosan-incorporated MOs are an interesting class of support matrices for enhancing the biological function, compared to other support matrices. Therefore, the importance of this study lies in exploiting chitosan as a carrier not of one metal as in previous studies, but of two metals in the form of a nanocomposite to carry out several biological functions. The coprecipitation approach was employed to synthesize chitosan/Fe
2
O
3
/ZnO-nanocomposite in the present research. The characterization of chitosan/Fe
2
O
3
/ZnO-nanocomposite was performed to find out the morphology and dispersion properties of chitosan/Fe
2
O
3
/ZnO-nanocomposite. The X-ray diffraction (XRD) investigation revealed that these were crystalline. Fourier transforms infrared (FTIR) spectrum bands were viewed at 400/cm and 900/cm, due to the stretching vibration of Fe and Zn oxygen bond. TEM showed that chitosan/Fe
2
O
3
/ZnO-nanocomposite was of 20–95 nm in size. chitosan/Fe
2
O
3
/ZnO-nanocomposite exhibited inhibitory potential against
Staphylococcus aureus
,
Bacillus subtilis, Escherichia coli
, and
Candida albicans
with inhibition zones of 25 ± 0.1, 28 ± 0.2, 27 ± 0.1, and 27 ± 0.2 mm, respectively while didn’t inhibited
Aspergillus niger
. MIC value of nanocomposite was 15.62 ± 0.33 µg/mL for
C. albicans, B. subtilis
and
E. coli
, while it was 62.50 ± 0.66 µg/mL for
Pseudomonas aeruginosa
. Ranged values of nanocomposite MBC (15.62 ± 0.33 to 125 ± 1 µg/mL) were attributed to all tested bacteria. Different concentrations of chitosan/Fe
2
O
3
/ZnO-nanocomposite MBC (25, 50, and 75%) reflected anti-biofilm activity against
E. coli
(85.0, 93.2, and 96.0%),
B. subtilis
(84.88, 92.21, and 96.99%),
S. aureus
81.64, 90.52, and 94.64%) and
P. aurogenosa
(90.11, 94.43, and 98.24%), respectively. The differences in the levels of antimicrobial activities may depend on the type of examined microbes. Antioxidant activity of chitosan/Fe
2
O
3
/ZnO-nanocomposite was recorded with excellent IC
50
values of 16.06 and 32.6 µg/mL using DPPH and ABTS scavenging, respectively. Wound heal by chitosan/Fe
2
O
3
/ZnO-nanocomposite was achieved with 100% compared to the untreated cells (76.75% of wound closer). The cytotoxicity outcomes showed that the IC
50
of the chitosan/Fe
2
O
3
/ZnO-nanocomposite was 564.32 ± 1.46 µg/mL normal WI-38 cells. Based on the achieved findings, the chitosan/Fe
2
O
3
/ZnO-nanocomposite is a very promising agent for perform pharmacological activities.</description><identifier>ISSN: 2468-0842</identifier><identifier>ISSN: 2468-0834</identifier><identifier>EISSN: 2468-0842</identifier><identifier>DOI: 10.1186/s13765-024-00926-2</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Antimicrobial ; antimicrobial properties ; Antioxidant ; antioxidant activity ; Applied Microbiology ; Aspergillus niger ; Bacillus subtilis ; Bimetallic ; Biofilms ; Biological Techniques ; Bioorganic Chemistry ; Biopolymers ; Candida albicans ; Chemistry ; Chemistry and Materials Science ; Chitosan ; class ; Coprecipitation ; Cytotoxicity ; E coli ; Escherichia coli ; Ferric oxide ; Fourier transforms ; Infrared radiation ; Iron ; Metal oxides ; Metals ; Nanocomposite ; Nanocomposites ; Nanoparticles ; oxygen ; Pseudomonas aeruginosa ; Scavenging ; Staphylococcus aureus ; vibration ; Wounds ; X-ray diffraction ; Zinc oxide ; 농학</subject><ispartof>Applied Biological Chemistry, 2024, 67(0), , pp.1-13</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c448t-31472fbf768dd56ddec09737379a2fa8672aad3a5e12e3c0c8d82f0debea9d163</cites><orcidid>0000-0001-6418-5890</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3098051187?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003110255$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Rajhi, Aisha M. H.</creatorcontrib><creatorcontrib>Abdelghany, Tarek M.</creatorcontrib><creatorcontrib>Almuhayawi, Mohammed S.</creatorcontrib><creatorcontrib>Alruhaili, Mohammed H.</creatorcontrib><creatorcontrib>Al Jaouni, Soad K.</creatorcontrib><creatorcontrib>Selim, Samy</creatorcontrib><title>The green approach of chitosan/Fe2O3/ZnO-nanocomposite synthesis with an evaluation of its biological activities</title><title>Applied biological chemistry</title><addtitle>Appl Biol Chem</addtitle><description>Biopolymers embedded with nanoparticles of metal oxides (MOs) demonstrate a wide range of bio-functions. Chitosan-incorporated MOs are an interesting class of support matrices for enhancing the biological function, compared to other support matrices. Therefore, the importance of this study lies in exploiting chitosan as a carrier not of one metal as in previous studies, but of two metals in the form of a nanocomposite to carry out several biological functions. The coprecipitation approach was employed to synthesize chitosan/Fe
2
O
3
/ZnO-nanocomposite in the present research. The characterization of chitosan/Fe
2
O
3
/ZnO-nanocomposite was performed to find out the morphology and dispersion properties of chitosan/Fe
2
O
3
/ZnO-nanocomposite. The X-ray diffraction (XRD) investigation revealed that these were crystalline. Fourier transforms infrared (FTIR) spectrum bands were viewed at 400/cm and 900/cm, due to the stretching vibration of Fe and Zn oxygen bond. TEM showed that chitosan/Fe
2
O
3
/ZnO-nanocomposite was of 20–95 nm in size. chitosan/Fe
2
O
3
/ZnO-nanocomposite exhibited inhibitory potential against
Staphylococcus aureus
,
Bacillus subtilis, Escherichia coli
, and
Candida albicans
with inhibition zones of 25 ± 0.1, 28 ± 0.2, 27 ± 0.1, and 27 ± 0.2 mm, respectively while didn’t inhibited
Aspergillus niger
. MIC value of nanocomposite was 15.62 ± 0.33 µg/mL for
C. albicans, B. subtilis
and
E. coli
, while it was 62.50 ± 0.66 µg/mL for
Pseudomonas aeruginosa
. Ranged values of nanocomposite MBC (15.62 ± 0.33 to 125 ± 1 µg/mL) were attributed to all tested bacteria. Different concentrations of chitosan/Fe
2
O
3
/ZnO-nanocomposite MBC (25, 50, and 75%) reflected anti-biofilm activity against
E. coli
(85.0, 93.2, and 96.0%),
B. subtilis
(84.88, 92.21, and 96.99%),
S. aureus
81.64, 90.52, and 94.64%) and
P. aurogenosa
(90.11, 94.43, and 98.24%), respectively. The differences in the levels of antimicrobial activities may depend on the type of examined microbes. Antioxidant activity of chitosan/Fe
2
O
3
/ZnO-nanocomposite was recorded with excellent IC
50
values of 16.06 and 32.6 µg/mL using DPPH and ABTS scavenging, respectively. Wound heal by chitosan/Fe
2
O
3
/ZnO-nanocomposite was achieved with 100% compared to the untreated cells (76.75% of wound closer). The cytotoxicity outcomes showed that the IC
50
of the chitosan/Fe
2
O
3
/ZnO-nanocomposite was 564.32 ± 1.46 µg/mL normal WI-38 cells. Based on the achieved findings, the chitosan/Fe
2
O
3
/ZnO-nanocomposite is a very promising agent for perform pharmacological activities.</description><subject>Antimicrobial</subject><subject>antimicrobial properties</subject><subject>Antioxidant</subject><subject>antioxidant activity</subject><subject>Applied Microbiology</subject><subject>Aspergillus niger</subject><subject>Bacillus subtilis</subject><subject>Bimetallic</subject><subject>Biofilms</subject><subject>Biological Techniques</subject><subject>Bioorganic Chemistry</subject><subject>Biopolymers</subject><subject>Candida albicans</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chitosan</subject><subject>class</subject><subject>Coprecipitation</subject><subject>Cytotoxicity</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Ferric oxide</subject><subject>Fourier transforms</subject><subject>Infrared radiation</subject><subject>Iron</subject><subject>Metal oxides</subject><subject>Metals</subject><subject>Nanocomposite</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>oxygen</subject><subject>Pseudomonas aeruginosa</subject><subject>Scavenging</subject><subject>Staphylococcus aureus</subject><subject>vibration</subject><subject>Wounds</subject><subject>X-ray diffraction</subject><subject>Zinc oxide</subject><subject>농학</subject><issn>2468-0842</issn><issn>2468-0834</issn><issn>2468-0842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk9r3DAQxU1poSHJF-jJ0EspuKs_tiwfQ2jahcBC2V56EWNpbGvjlbaSNiHfvtp1aEsPRYcR4veehplXFO8o-USpFKtIeSuairC6IqRjomKvigtWC1kRWbPXf93fFtcx7gghVEjBGn5RHLYTlmNAdCUcDsGDnko_lHqyyUdwqztkG7764TaVA-e13x98tAnL-OzShNHG8smmqQRX4iPMR0jWu5OBTbHsrZ_9aDXMJehkH22yGK-KNwPMEa9f6mXx_e7z9vZrdb_5sr69ua90XctUcVq3bOiHVkhjGmEMatK1PJ8O2ABStAzAcGiQMuSaaGkkG4jBHqEzVPDL4uPi68KgHrRVHuy5jl49BHXzbbtWlAhGSSszvF5g42GnDsHuITyfFecHH0YFIVk9o2J1V0vsTD9oUbeE9C3tkBiTm4W277vs9WHxytP8ecSY1N5GjfMMDv0xKk6bvC7K6Onb9_-gO38MLo9FcdJJ0uT1tpliC6WDjzHg8LtBStQpAGoJgMoBUOcAKJZFfBHFDLsRwx_r_6h-AZeHs0E</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Al-Rajhi, Aisha M. H.</creator><creator>Abdelghany, Tarek M.</creator><creator>Almuhayawi, Mohammed S.</creator><creator>Alruhaili, Mohammed H.</creator><creator>Al Jaouni, Soad K.</creator><creator>Selim, Samy</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><general>SpringerOpen</general><general>한국응용생명화학회</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7S9</scope><scope>L.6</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0001-6418-5890</orcidid></search><sort><creationdate>20241201</creationdate><title>The green approach of chitosan/Fe2O3/ZnO-nanocomposite synthesis with an evaluation of its biological activities</title><author>Al-Rajhi, Aisha M. H. ; Abdelghany, Tarek M. ; Almuhayawi, Mohammed S. ; Alruhaili, Mohammed H. ; Al Jaouni, Soad K. ; Selim, Samy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-31472fbf768dd56ddec09737379a2fa8672aad3a5e12e3c0c8d82f0debea9d163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antimicrobial</topic><topic>antimicrobial properties</topic><topic>Antioxidant</topic><topic>antioxidant activity</topic><topic>Applied Microbiology</topic><topic>Aspergillus niger</topic><topic>Bacillus subtilis</topic><topic>Bimetallic</topic><topic>Biofilms</topic><topic>Biological Techniques</topic><topic>Bioorganic Chemistry</topic><topic>Biopolymers</topic><topic>Candida albicans</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chitosan</topic><topic>class</topic><topic>Coprecipitation</topic><topic>Cytotoxicity</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Ferric oxide</topic><topic>Fourier transforms</topic><topic>Infrared radiation</topic><topic>Iron</topic><topic>Metal oxides</topic><topic>Metals</topic><topic>Nanocomposite</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>oxygen</topic><topic>Pseudomonas aeruginosa</topic><topic>Scavenging</topic><topic>Staphylococcus aureus</topic><topic>vibration</topic><topic>Wounds</topic><topic>X-ray diffraction</topic><topic>Zinc oxide</topic><topic>농학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Rajhi, Aisha M. H.</creatorcontrib><creatorcontrib>Abdelghany, Tarek M.</creatorcontrib><creatorcontrib>Almuhayawi, Mohammed S.</creatorcontrib><creatorcontrib>Alruhaili, Mohammed H.</creatorcontrib><creatorcontrib>Al Jaouni, Soad K.</creatorcontrib><creatorcontrib>Selim, Samy</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>Agricultural Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Applied biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Rajhi, Aisha M. H.</au><au>Abdelghany, Tarek M.</au><au>Almuhayawi, Mohammed S.</au><au>Alruhaili, Mohammed H.</au><au>Al Jaouni, Soad K.</au><au>Selim, Samy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The green approach of chitosan/Fe2O3/ZnO-nanocomposite synthesis with an evaluation of its biological activities</atitle><jtitle>Applied biological chemistry</jtitle><stitle>Appl Biol Chem</stitle><date>2024-12-01</date><risdate>2024</risdate><volume>67</volume><issue>1</issue><spage>75</spage><epage>75</epage><pages>75-75</pages><artnum>75</artnum><issn>2468-0842</issn><issn>2468-0834</issn><eissn>2468-0842</eissn><abstract>Biopolymers embedded with nanoparticles of metal oxides (MOs) demonstrate a wide range of bio-functions. Chitosan-incorporated MOs are an interesting class of support matrices for enhancing the biological function, compared to other support matrices. Therefore, the importance of this study lies in exploiting chitosan as a carrier not of one metal as in previous studies, but of two metals in the form of a nanocomposite to carry out several biological functions. The coprecipitation approach was employed to synthesize chitosan/Fe
2
O
3
/ZnO-nanocomposite in the present research. The characterization of chitosan/Fe
2
O
3
/ZnO-nanocomposite was performed to find out the morphology and dispersion properties of chitosan/Fe
2
O
3
/ZnO-nanocomposite. The X-ray diffraction (XRD) investigation revealed that these were crystalline. Fourier transforms infrared (FTIR) spectrum bands were viewed at 400/cm and 900/cm, due to the stretching vibration of Fe and Zn oxygen bond. TEM showed that chitosan/Fe
2
O
3
/ZnO-nanocomposite was of 20–95 nm in size. chitosan/Fe
2
O
3
/ZnO-nanocomposite exhibited inhibitory potential against
Staphylococcus aureus
,
Bacillus subtilis, Escherichia coli
, and
Candida albicans
with inhibition zones of 25 ± 0.1, 28 ± 0.2, 27 ± 0.1, and 27 ± 0.2 mm, respectively while didn’t inhibited
Aspergillus niger
. MIC value of nanocomposite was 15.62 ± 0.33 µg/mL for
C. albicans, B. subtilis
and
E. coli
, while it was 62.50 ± 0.66 µg/mL for
Pseudomonas aeruginosa
. Ranged values of nanocomposite MBC (15.62 ± 0.33 to 125 ± 1 µg/mL) were attributed to all tested bacteria. Different concentrations of chitosan/Fe
2
O
3
/ZnO-nanocomposite MBC (25, 50, and 75%) reflected anti-biofilm activity against
E. coli
(85.0, 93.2, and 96.0%),
B. subtilis
(84.88, 92.21, and 96.99%),
S. aureus
81.64, 90.52, and 94.64%) and
P. aurogenosa
(90.11, 94.43, and 98.24%), respectively. The differences in the levels of antimicrobial activities may depend on the type of examined microbes. Antioxidant activity of chitosan/Fe
2
O
3
/ZnO-nanocomposite was recorded with excellent IC
50
values of 16.06 and 32.6 µg/mL using DPPH and ABTS scavenging, respectively. Wound heal by chitosan/Fe
2
O
3
/ZnO-nanocomposite was achieved with 100% compared to the untreated cells (76.75% of wound closer). The cytotoxicity outcomes showed that the IC
50
of the chitosan/Fe
2
O
3
/ZnO-nanocomposite was 564.32 ± 1.46 µg/mL normal WI-38 cells. Based on the achieved findings, the chitosan/Fe
2
O
3
/ZnO-nanocomposite is a very promising agent for perform pharmacological activities.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1186/s13765-024-00926-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6418-5890</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2468-0842 |
| ispartof | Applied Biological Chemistry, 2024, 67(0), , pp.1-13 |
| issn | 2468-0842 2468-0834 2468-0842 |
| language | eng |
| recordid | cdi_nrf_kci_oai_kci_go_kr_ARTI_10621078 |
| source | Springer Nature Link Journals Open Access; ProQuest Publicly Available Content Database |
| subjects | Antimicrobial antimicrobial properties Antioxidant antioxidant activity Applied Microbiology Aspergillus niger Bacillus subtilis Bimetallic Biofilms Biological Techniques Bioorganic Chemistry Biopolymers Candida albicans Chemistry Chemistry and Materials Science Chitosan class Coprecipitation Cytotoxicity E coli Escherichia coli Ferric oxide Fourier transforms Infrared radiation Iron Metal oxides Metals Nanocomposite Nanocomposites Nanoparticles oxygen Pseudomonas aeruginosa Scavenging Staphylococcus aureus vibration Wounds X-ray diffraction Zinc oxide 농학 |
| title | The green approach of chitosan/Fe2O3/ZnO-nanocomposite synthesis with an evaluation of its biological activities |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-03-07T09%3A28%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20green%20approach%20of%20chitosan/Fe2O3/ZnO-nanocomposite%20synthesis%20with%20an%20evaluation%20of%20its%20biological%20activities&rft.jtitle=Applied%20biological%20chemistry&rft.au=Al-Rajhi,%20Aisha%20M.%20H.&rft.date=2024-12-01&rft.volume=67&rft.issue=1&rft.spage=75&rft.epage=75&rft.pages=75-75&rft.artnum=75&rft.issn=2468-0842&rft.eissn=2468-0842&rft_id=info:doi/10.1186/s13765-024-00926-2&rft_dat=%3Cproquest_nrf_k%3E3153761218%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c448t-31472fbf768dd56ddec09737379a2fa8672aad3a5e12e3c0c8d82f0debea9d163%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3098051187&rft_id=info:pmid/&rfr_iscdi=true |