Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

A buccal delivery system provides a much milder environment for drug delivery compared to an oral delivery which presents a hostile environment for drugs, especially proteins and polypeptides, owing to acid hydrolysis. Local delivery in an oral cavity has particular applications in the treatment of...

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Bibliographic Details
Published in:Journal of the Korean Physical Society 2015, 66(1), , pp.17-21
Main Authors: Nho, Young-Chang, Park, Jong-Seok, Shin, Jung-Woong, Lim, Youn-Mook, Jeong, Sung-In, Shin, Young-Min, Gwon, Hui-Jeong, Khil, Myung-Seob, Lee, Deok-Won, Ahn, Sung-Jun
Format: Article
Language:English
Subjects:
Acrylics
Adhesion
Adhesive strength
Bacterial diseases
Drug delivery systems
Electron beams
Gamma rays
Hydrogels
Irradiation
Mathematical and Computational Physics
Particle and Nuclear Physics
Periodontal disease
Physical properties
Physics
Physics and Astronomy
Polyacrylic acid
Polyethylene glycol
Polypeptides
Theoretical
Water purification
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Summary:A buccal delivery system provides a much milder environment for drug delivery compared to an oral delivery which presents a hostile environment for drugs, especially proteins and polypeptides, owing to acid hydrolysis. Local delivery in an oral cavity has particular applications in the treatment of toothaches, periodontal disease, and bacterial infections. Poly(acrylic acid) (PAA)-based hydrogels prepared using a chemical initiator have been attempted for a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, PAA and polyethylene glycol (PEG) were selected to prepare using a radiation process a bioadhesive hydrogel for adhesion to mucosal surfaces. PAA and PEG were dissolved in purified water to prepare a homogeneous PAA/PEG solution, and the solution was then irradiated using an electron beam at dose up to 70 kGy to make the hydrogels. Their physical properties, such as gel percent, swelling percent, and adhesive strength to mucosal surfaces, were investigated. In this experiment, various amounts of PEG were incorporated into the PAA to enhance the mucoadhesive property of the hydrogels. The effect of the molecular weight of PEG on the mucoadhesion was also examined.
ISSN:0374-4884
1976-8524
DOI:10.3938/jkps.66.17