High Serum miR-361-3p Predicts Early Postdischarge Infections after Autologous Stem Cell Transplantation

• Published in: Infection & chemotherapy 2024, 56(3), , pp.339-350
• Main Authors: Mikulski, Damian, Kościelny, Kacper, Dróżdż, Izabela, Nowicki, Mateusz, Misiewicz, Małgorzata, Perdas, Ewelina, Strzałka, Piotr, Wierzbowska, Agnieszka, Fendler, Wojciech
• Format: Article
• Language: English
• Subjects: Original; 내과학
• ISSN: 2093-2340; 2092-6448
• DOI: 10.3947/ic.2024.0021

Autologous hematopoietic stem cell transplantation (AHSCT) is currently the backbone of the treatment of multiple myeloma (MM) and relapsed and refractory lymphomas. Notably, infections contribute to over 25% of fatalities among AHSCT recipients within the initial 100 days following the procedure. In this study, we aimed to evaluate three selected miRNAs: hsa-miR-155-5p, hsa-miR-320c, and hsa-miR-361-3p, in identifying AHSCT recipients at high risk of infectious events up to 100 days post-transplantation after discharge. The study group consisted of 58 patients (43 with MM, 15 with lymphoma) treated with AHSCT. Blood samples were collected from all patients at the same time point: on day +14 after transplantation. Fifteen patients (25.9%) experienced infectious complications after post-transplant discharge within the initial +100 days post-transplantation. The median time to infection onset was 44 days (interquartile range, 25-78). Four patients required hospitalization due to severe infection. High expression of hsa-miR-361-3p (fold change [FC], 1.79; =0.0139) in the patients experiencing infectious complications and overexpression of hsa-miR-320c (FC, 2.14;