Influence of cancer in pregnancy on obstetric and neonatal outcomes: an observational retrospective cohort study

The study aimed to review the oncological characteristics and treatment of pregnancy-associated cancers and analyze the obstetric and neonatal outcomes to provide evidence-based recommendations for reproductive function preservation, oncological treatment, and obstetric management. We conducted an o...

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Bibliographic Details
Published in:Journal of gynecologic oncology 2024, 35(6), , pp.1-13
Main Authors: Huang, Xuan, Zhang, Chen, Zhu, Jialei, Li, Yueyan, Tang, Jing
Format: Article
Language:English
Subjects:
Abortion, Induced - statistics & numerical data
Adult
China - epidemiology
Female
Humans
Infant, Newborn
Infant, Small for Gestational Age
Original
Pregnancy
Pregnancy Complications, Neoplastic - drug therapy
Pregnancy Complications, Neoplastic - epidemiology
Pregnancy Complications, Neoplastic - therapy
Pregnancy Outcome - epidemiology
Premature Birth - epidemiology
Retrospective Studies
Taxoids - administration & dosage
산부인과학
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Summary:The study aimed to review the oncological characteristics and treatment of pregnancy-associated cancers and analyze the obstetric and neonatal outcomes to provide evidence-based recommendations for reproductive function preservation, oncological treatment, and obstetric management. We conducted an observational retrospective cohort study among pregnant patients with cancer in 7 Chinese tertiary A hospitals from 2003 to 2021. We conducted multiple logistic regression to determine the influence of various factors on preterm birth and small-for-gestational-age infants, log-binomial regression to analyze temporal changes, and χ² tests to explore the effects of cancer type/treatment. Of 204 women, 17% terminated their pregnancies; 59% received pre-delivery treatment. Every 6 years, the rates of pregnancy termination (relative risk [RR]=0.48; 95% confidence interval [CI]=0.35-0.67) and iatrogenic preterm births (RR=0.73; 95% CI=0.54-0.98) reduced, and that of pre-delivery treatment increased, mainly due to increased rates of surgery (RR=1.87; 95% CI=1.31-2.67). Maternal systemic diseases were related to small-for-gestational-age infants (odds ratio [OR]=12.02; 95% CI=1.82-79.43). Chemotherapy with taxanes plus platinum-based agents was related to adverse obstetric outcomes (OR=1.87; 95% CI=1.42-2.46; p
ISSN:2005-0380
2005-0399
2005-0399
DOI:10.3802/jgo.2024.35.e74