Resveratrol regulates naïve CD 8 + T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression

We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regu...

Full description

Saved in:
Bibliographic Details
Published in:BMB reports 2015, 48(5), , pp.283-288
Main Authors: Noh, Kyung Tae, Cho, Joon, Chun, Sung Hak, Jang, Jong-Hwa, Cha, Gil Sun, Jung, In Duk, Jang, Dong Deuk, Park, Yeong-Min
Format: Article
Language:English
Subjects:
화학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naïve CD8 + T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8 + T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-γ-induced TTS expression in a GSK-3β-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. [BMB Reports 2015; 48(5): 283-288]
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2015.48.5.190