Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B

Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction wi...

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Published in:BMB reports 2015, 48(7), , pp.401-406
Main Authors: Han, A., Chung-Ang University, Seoul, Republic of Korea, Chae, Y.C., Chung-Ang University, Seoul, Republic of Korea, Park, J.W., Chung-Ang University, Seoul, Republic of Korea, Kim, K.B., Chung-Ang University, Seoul, Republic of Korea, Kim, J.Y., Chung-Ang University, Seoul, Republic of Korea, Seo, S.B., Chung-Ang University, Seoul, Republic of Korea
Format: Article
Language:English
Subjects:
ANGPT1,Cell motility,KDM3B, SMRT
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Summary:Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction with SMRT, and suggest that the repressor complex is formed at the promoter area of ANGPT1. Using MTT and wound healing assays, depletion of KDM3B was found to increase cell proliferation and cell motility, indicating that KDM3B has a role in angiogenesis.
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2015.48.7.188