Anticoagulant activities of curcumin and its derivative

Curcumin, a polyphenol responsible for the yellow color of the curry spice turmeric, possesses antiinflammatory, antiproliferative and antiangiogenic activities. However, anticoagulant activities of curcumin have not been studied. Here, the anticoagulant properties of curcumin and its derivative (bi...

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Bibliographic Details
Published in:BMB reports 2012, 45(4), , pp.221-226
Main Authors: Kim, D.C., NEUORNEX Inc., Daegu, Republic of Korea, Ku, S.K., Daegu Haany University, Gyeongsan, Republic of Korea, Bae, J.S., Kyungpook National University, Daegu, Republic of Korea
Format: Article
Language:English
Subjects:
aPTT
CURCUMA LONGA
Curcumin
DYES
HUVECs
TEINTURE
TINTES
화학
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Summary:Curcumin, a polyphenol responsible for the yellow color of the curry spice turmeric, possesses antiinflammatory, antiproliferative and antiangiogenic activities. However, anticoagulant activities of curcumin have not been studied. Here, the anticoagulant properties of curcumin and its derivative (bisdemethoxycurcumin, BDMC) were determined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT) as well as cell-based thrombin and activated factor X (FXa) generation activities. Data showed that curcumin and BDMC prolonged aPTT and PT significantly and inhibited thrombin and FXa activities. They inhibited the generation of thrombin or FXa. In accordance with these anticoagulant activities, curcumin and BDMC showed anticoagulant effect in vivo. Surprisingly, these anticoagulant effects of curcumin were better than those of BDMC indicating that methoxy group in curcumin positively regulated anticoagulant function of curcumin. Therefore, these results suggest that curcumin and BDMC possess antithrombotic activities and daily consumption of the curry spice turmeric might help maintain anticoagulant status.
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2012.45.4.221