Altered PLCβ-1 expression in the gerbil hippocampal complex following spontaneous seizure

Although the phospholipase C (PLC)β-1 isoform is associated with spontaneous seizure and distinctively expressed in the telencephalon, the distribution of PLCβ-1 expression in the epileptic gerbil hippocampus remains controversial. Therefore, we determined whether PLCβ-1 is associated with spontaneo...

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Published in:BMB reports 2011, 44(9), , pp.566-571
Main Authors: Lee, S.B., Soonchunhyang University, Cheonan, Republic of Korea, Oh, Y.J., Soonchunhyang University, Cheonan, Republic of Korea, Chung, J.K., Soonchunhyang University, Cheonan, Republic of Korea, Jeong, J.H., Soonchunhyang University, Cheonan, Republic of Korea, Lee, S.D., Hallym University, Chuncheon, Republic of Korea, Park, D.K., Soonchunhyang University, Cheonan, Republic of Korea, Park, K.H., Soonchunhyang University, Cheonan, Republic of Korea, Ko, J.S., Soonchunhyang University, Cheonan, Republic of Korea, Kim, D.S., Soonchunhyang University, Cheonan, Republic of Korea
Format: Article
Language:English
Subjects:
EPILEPSIA
EPILEPSIE
EPILEPSY
GERBILLE
GERBILS
GERBO
Hippocampus
Immunohistochemistry
Phospholipase C
화학
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Summary:Although the phospholipase C (PLC)β-1 isoform is associated with spontaneous seizure and distinctively expressed in the telencephalon, the distribution of PLCβ-1 expression in the epileptic gerbil hippocampus remains controversial. Therefore, we determined whether PLCβ-1 is associated with spontaneous seizure in an animal model of genetic epilepsy. In the present study, PLCβ-1 immunoreactivity was down-regulated in seizure-sensitive (SS) gerbils more than in seizure-resistant (SR) gerbils. The expression of PLCβ-1 within calretinin (CR)-positive neurons was rarely detected within the dentate hilar region of SS gerbils. PLCβ-1 immunoreactivity in the hippocampus was significantly elevated as compared to that in pre-seizure SS gerbil 3 h post-ictal. These findings suggest that alterations in PLCβ-1 immunoreactivity in the SS gerbil hippocampus may be closely related to the epileptic state of the gerbil brain and transiently elevated PLCβ-1 protein levels following seizure episodes. Such alterations may be compensatory responses in the SS gerbil hippocampus.
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2011.44.9.566