Role of placenta growth factor in cancer and inflammation

Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF w...

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Bibliographic Details
Published in:Experimental & molecular medicine 2012, 44(1), , pp.10-19
Main Authors: Kim, Ki-Jo, Cho, Chul-Soo, Kim, Wan-Uk
Format: Article
Language:English
Subjects:
Animals
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Atherosclerosis - metabolism
Atherosclerosis - pathology
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Humans
Inflammation - metabolism
Medical Biochemistry
Molecular Medicine
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic
Placenta Growth Factor
Pregnancy Proteins - metabolism
Review
Signal Transduction
Stem Cells
생화학
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Summary:Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF was discovered having a proinflammatory role in inflammatory arthritis and its serum level drew attention not only as a useful surrogate biomarker but also a potential therapeutic target in atherosclerosis and various cancers. Particularly, PlGF has attractive clinical values because endogenous PlGF is redundant for vascular development and physiological vessel maintenance in healthy adults. However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required.
ISSN:1226-3613
2092-6413
DOI:10.3858/emm.2012.44.1.023