Role of placenta growth factor in cancer and inflammation

Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF w...

Full description

Saved in:
Bibliographic Details
Published in:Experimental & molecular medicine 2012, 44(1), , pp.10-19
Main Authors: Kim, Ki-Jo, Cho, Chul-Soo, Kim, Wan-Uk
Format: Article
Language:English
Subjects:
Animals
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Atherosclerosis - metabolism
Atherosclerosis - pathology
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Humans
Inflammation - metabolism
Medical Biochemistry
Molecular Medicine
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic
Placenta Growth Factor
Pregnancy Proteins - metabolism
Review
Signal Transduction
Stem Cells
생화학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3
cites cdi_FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3
container_end_page 19
container_issue 1
container_start_page 10
container_title Experimental & molecular medicine
container_volume 44
creator Kim, Ki-Jo
Cho, Chul-Soo
Kim, Wan-Uk
description Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF was discovered having a proinflammatory role in inflammatory arthritis and its serum level drew attention not only as a useful surrogate biomarker but also a potential therapeutic target in atherosclerosis and various cancers. Particularly, PlGF has attractive clinical values because endogenous PlGF is redundant for vascular development and physiological vessel maintenance in healthy adults. However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required.
doi_str_mv 10.3858/emm.2012.44.1.023
format article
fullrecord <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_1089204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4103366281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3</originalsourceid><addsrcrecordid>eNp9kV1rFDEUhoModl39Ad7IgBfqxYw5J5l83BRK8aNQEEq9DpnZZDvtTLIms4r_3ky3liroTQ7hPO-bc_IS8hJow1Sr3rtpapACNpw30FBkj8gKqcZacGCPyQoQRc0EsCPyLOdrSrHlkj8lR4gIknO1Ivoijq6KvtqNtndhttU2xR_zVeVtP8dUDaHqbehdqmzYlJsf7TTZeYjhOXni7Zjdi7u6Jl8_frg8_Vyff_l0dnpyXveC4lwrLbRt3YY5K2UnnETUyJXU4D3oVkDrVNdKpXzHUaLUkvpysp4zhrRzbE3eHXxD8uamH0y0w23dRnOTzMnF5ZkBqjRSXtjjA7vbd5PbLAslO5pdGiabft4q_-yE4ar4fDcMpVSaFYM3dwYpftu7PJtpyL0bRxtc3GejQZeZmVzIt_8lQVElFNCWFvT1X-h13KdQPm2hKHDBS15rAgeqTzHn5Pz92EDNErcpcZslbsO5AVPiLppXD_e9V_zOtwB4AHJpha1LD57-p-svXuKzvw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1800146441</pqid></control><display><type>article</type><title>Role of placenta growth factor in cancer and inflammation</title><source>Open Access: PubMed Central</source><source>Publicly Available Content (ProQuest)</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Kim, Ki-Jo ; Cho, Chul-Soo ; Kim, Wan-Uk</creator><creatorcontrib>Kim, Ki-Jo ; Cho, Chul-Soo ; Kim, Wan-Uk</creatorcontrib><description>Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF was discovered having a proinflammatory role in inflammatory arthritis and its serum level drew attention not only as a useful surrogate biomarker but also a potential therapeutic target in atherosclerosis and various cancers. Particularly, PlGF has attractive clinical values because endogenous PlGF is redundant for vascular development and physiological vessel maintenance in healthy adults. However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required.</description><identifier>ISSN: 1226-3613</identifier><identifier>EISSN: 2092-6413</identifier><identifier>DOI: 10.3858/emm.2012.44.1.023</identifier><identifier>PMID: 22217448</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Humans ; Inflammation - metabolism ; Medical Biochemistry ; Molecular Medicine ; Neoplasms - metabolism ; Neoplasms - pathology ; Neovascularization, Pathologic ; Placenta Growth Factor ; Pregnancy Proteins - metabolism ; Review ; Signal Transduction ; Stem Cells ; 생화학</subject><ispartof>Experimental and Molecular Medicine, 2012, 44(1), , pp.10-19</ispartof><rights>The Author(s) 2012</rights><rights>Copyright Nature Publishing Group Jan 2012</rights><rights>Copyright © 2012 Korean Society for Biochemistry and Molecular Biology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3</citedby><cites>FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1800146441/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1800146441?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22217448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001629885$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ki-Jo</creatorcontrib><creatorcontrib>Cho, Chul-Soo</creatorcontrib><creatorcontrib>Kim, Wan-Uk</creatorcontrib><title>Role of placenta growth factor in cancer and inflammation</title><title>Experimental &amp; molecular medicine</title><addtitle>Exp Mol Med</addtitle><addtitle>Exp Mol Med</addtitle><description>Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF was discovered having a proinflammatory role in inflammatory arthritis and its serum level drew attention not only as a useful surrogate biomarker but also a potential therapeutic target in atherosclerosis and various cancers. Particularly, PlGF has attractive clinical values because endogenous PlGF is redundant for vascular development and physiological vessel maintenance in healthy adults. However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required.</description><subject>Animals</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - pathology</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Humans</subject><subject>Inflammation - metabolism</subject><subject>Medical Biochemistry</subject><subject>Molecular Medicine</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neovascularization, Pathologic</subject><subject>Placenta Growth Factor</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Stem Cells</subject><subject>생화학</subject><issn>1226-3613</issn><issn>2092-6413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kV1rFDEUhoModl39Ad7IgBfqxYw5J5l83BRK8aNQEEq9DpnZZDvtTLIms4r_3ky3liroTQ7hPO-bc_IS8hJow1Sr3rtpapACNpw30FBkj8gKqcZacGCPyQoQRc0EsCPyLOdrSrHlkj8lR4gIknO1Ivoijq6KvtqNtndhttU2xR_zVeVtP8dUDaHqbehdqmzYlJsf7TTZeYjhOXni7Zjdi7u6Jl8_frg8_Vyff_l0dnpyXveC4lwrLbRt3YY5K2UnnETUyJXU4D3oVkDrVNdKpXzHUaLUkvpysp4zhrRzbE3eHXxD8uamH0y0w23dRnOTzMnF5ZkBqjRSXtjjA7vbd5PbLAslO5pdGiabft4q_-yE4ar4fDcMpVSaFYM3dwYpftu7PJtpyL0bRxtc3GejQZeZmVzIt_8lQVElFNCWFvT1X-h13KdQPm2hKHDBS15rAgeqTzHn5Pz92EDNErcpcZslbsO5AVPiLppXD_e9V_zOtwB4AHJpha1LD57-p-svXuKzvw</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Kim, Ki-Jo</creator><creator>Cho, Chul-Soo</creator><creator>Kim, Wan-Uk</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>Korean Society for Biochemistry and Molecular Biology</general><general>생화학분자생물학회</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope></search><sort><creationdate>2012</creationdate><title>Role of placenta growth factor in cancer and inflammation</title><author>Kim, Ki-Jo ; Cho, Chul-Soo ; Kim, Wan-Uk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Atherosclerosis - metabolism</topic><topic>Atherosclerosis - pathology</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Humans</topic><topic>Inflammation - metabolism</topic><topic>Medical Biochemistry</topic><topic>Molecular Medicine</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neovascularization, Pathologic</topic><topic>Placenta Growth Factor</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>Stem Cells</topic><topic>생화학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ki-Jo</creatorcontrib><creatorcontrib>Cho, Chul-Soo</creatorcontrib><creatorcontrib>Kim, Wan-Uk</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Experimental &amp; molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ki-Jo</au><au>Cho, Chul-Soo</au><au>Kim, Wan-Uk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of placenta growth factor in cancer and inflammation</atitle><jtitle>Experimental &amp; molecular medicine</jtitle><stitle>Exp Mol Med</stitle><addtitle>Exp Mol Med</addtitle><date>2012</date><risdate>2012</risdate><volume>44</volume><issue>1</issue><spage>10</spage><epage>19</epage><pages>10-19</pages><issn>1226-3613</issn><eissn>2092-6413</eissn><abstract>Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF was discovered having a proinflammatory role in inflammatory arthritis and its serum level drew attention not only as a useful surrogate biomarker but also a potential therapeutic target in atherosclerosis and various cancers. Particularly, PlGF has attractive clinical values because endogenous PlGF is redundant for vascular development and physiological vessel maintenance in healthy adults. However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22217448</pmid><doi>10.3858/emm.2012.44.1.023</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1226-3613
ispartof Experimental and Molecular Medicine, 2012, 44(1), , pp.10-19
issn 1226-3613
2092-6413
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_1089204
source Open Access: PubMed Central; Publicly Available Content (ProQuest); Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access
subjects Animals
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Atherosclerosis - metabolism
Atherosclerosis - pathology
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Humans
Inflammation - metabolism
Medical Biochemistry
Molecular Medicine
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic
Placenta Growth Factor
Pregnancy Proteins - metabolism
Review
Signal Transduction
Stem Cells
생화학
title Role of placenta growth factor in cancer and inflammation
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A57%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20placenta%20growth%20factor%20in%20cancer%20and%20inflammation&rft.jtitle=Experimental%20&%20molecular%20medicine&rft.au=Kim,%20Ki-Jo&rft.date=2012&rft.volume=44&rft.issue=1&rft.spage=10&rft.epage=19&rft.pages=10-19&rft.issn=1226-3613&rft.eissn=2092-6413&rft_id=info:doi/10.3858/emm.2012.44.1.023&rft_dat=%3Cproquest_nrf_k%3E4103366281%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c602t-8969a5ed3ea77b6e7229248791ff195615e8b5788fb42727970f2793c43320be3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1800146441&rft_id=info:pmid/22217448&rfr_iscdi=true