Regulation of glucose metabolism-related genes and VEGF by HIF-1α and HIF-1β, but not HIF-2α, in gastric cancer

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution to the regulation of target genes related to angiogenesis and glucose me...

Full description

Saved in:
Bibliographic Details
Published in:Experimental & molecular medicine 2009, 41(1), , pp.51-58
Main Authors: Song, In-Sung, Wang, Ai-Guo, Yoon, Sun Young, Kim, Jeong-Min, Kim, Joo Heon, Lee, Dong-Seok, Kim, Nam-Soon
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Medical Biochemistry
Molecular Medicine
Original
Stem Cells
생화학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution to the regulation of target genes related to angiogenesis and glucose metabolism in gastric cancer. The data showed that HIFs were over-expressed in gastric cancer and that activation of the target genes was observed mainly in the early stages. Moreover, the results of the present study revealed that only HIF-1α, but not HIF-2α dimerizes with HIF-1β and then regulates expression of target genes in response to hypoxia. The results of the present study demonstrate that HIF-1α and HIF-1β enhances expression of VEGF and glucose metabolism-related genes in response to hypoxia in gastric cancer. These data offer important information regarding HIF pathways in the development of gastric cancer.
ISSN:1226-3613
2092-6413
DOI:10.3858/emm.2009.41.1.007