Antilipidemic effects and gene expression profiling of the glycosaminoglycans from cricket in rats on a high fat diet

Glycosaminoglycan (GAG) from cricket ( Gryllus bimaculatus ) was studied as a potential health supplement. Antiatherosclerotic and antilipidemic effects of the GAG of G . bimaculatus (GbG, 5 or 10 mg/kg) were investigated in 15-week old Wistar rats treated with GbG for over a month. GbG produced a m...

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Bibliographic Details
Published in:Archives of pharmacal research 2016, 39(7), , pp.926-936
Main Authors: Ahn, Mi Young, Hwang, Jae Sam, Kim, Min-Ji, Park, Kun-Koo
Format: Article
Language:English
Subjects:
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Animals
Body Weight - drug effects
Body Weight - physiology
Diet, High-Fat - adverse effects
Fatty Acids - antagonists & inhibitors
Fatty Acids - metabolism
Gene Expression Profiling - methods
Glycosaminoglycans - isolation & purification
Glycosaminoglycans - pharmacology
Gryllidae
Hypolipidemic Agents - isolation & purification
Hypolipidemic Agents - pharmacology
Male
Medicine
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Wistar
Research Article
약학
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Summary:Glycosaminoglycan (GAG) from cricket ( Gryllus bimaculatus ) was studied as a potential health supplement. Antiatherosclerotic and antilipidemic effects of the GAG of G . bimaculatus (GbG, 5 or 10 mg/kg) were investigated in 15-week old Wistar rats treated with GbG for over a month. GbG produced a meaningful anti-edema effect with inhibition of C-reactive protein (CRP). Also, the weights of abdominal and epididymidal fat were also reduced in conjunction with a mild increase in body weight. Furthermore, the sero-biochemical parameters showed an antihyperlipidemic effect with decreased levels of phospholipid, AST, ALT, total cholesterol and glucose in a dose-dependent manner. In addition anticoagulant and antithrombotic effects were seen: platelet, thrombin time, prothrombin time and Factor I were increased with GbG treatment. Furthermore, the GbG treated rat group (at 10 mg/kg) compared to control, showed that 588 genes (test/control ratio >2.0) including lipocalin 2 (Lcn2) and alpha 2-macroglobulin (A2 m) were up-regulated, and 569 genes (test/control ratio >0.5) including stearoyl-coenzyme A desaturase 1 (Scd1) were down-regulated. Based on these results, GbG could potentially prevent or treat fatty liver or hyperlipidemia in rats on a high-fat diet.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-016-0749-1