Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

• Published in: Archives of pharmacal research 2014, 37(7), , pp.916-926
• Main Authors: Ali, Gowhar, Subhan, Fazal, Islam, Nazar Ul, Ullah, Nasir, Shahid, Muhammad, Ullah, Sami, Ullah, Ihsan, Shah, Rehmat, Khan, Ikhtiar, Sewell, Robert D. E., Abbas, Ghulam
• Format: Article
• Language: English
• Subjects: Animals; Aspirin - chemistry; Aspirin - toxicity; Benzyl Alcohols - chemistry; Benzyl Alcohols - toxicity; Drug Evaluation, Preclinical - methods; Female; Gastric Mucosa - drug effects; Gastric Mucosa - pathology; Male; Medicine; Nitrogen - chemistry; Nitrogen - toxicity; Pharmacology/Toxicology; Pharmacy; Rats; Rats, Sprague-Dawley; Research Article; Stomach Ulcer - chemically induced; Stomach Ulcer - pathology; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-013-0245-9

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.