Loading…
Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava
The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition...
Saved in:
| Published in: | Archives of pharmacal research 2015, 38(12), , pp.2137-2142 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3 |
| container_end_page | 2142 |
| container_issue | 12 |
| container_start_page | 2137 |
| container_title | Archives of pharmacal research |
| container_volume | 38 |
| creator | Hussain, Hidayat Raees, Muhammad Adil Rehman, Najeeb Ur Al-Rawahi, Ahmed Csuk, René Khan, Husain Yar Abbas, Ghulam Al-Broumi, Mohammed Abdullah Green, Ivan R Elyassi, Ali Mahmood, Talat Al-Harrasi, Ahmed |
| description | The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC₅₀ of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition. |
| doi_str_mv | 10.1007/s12272-015-0653-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_1136838</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1738818445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3</originalsourceid><addsrcrecordid>eNp9kE1PHSEUhompqVfbH-CmZamLUT4GBrozaquJqWmra3KGgRGdGa5wr0Z_fbkd22XZnITzvG_gQWifkiNKSHOcKWMNqwgVFZGCV2QLLahuZMUbJd-hBWHlUjKpd9BuzveEcCmEeI92mORciFov0I_v4fUZcujcFwx4cs8YplWwMFmX8DK5foLJ4X54sXEDYZ_iiFd3DmdY4ujxmctj6GKydyFjP8ATfEDbHobsPr7NPXT79fzm9KK6uv52eXpyVVnB1ariUlvNODRtqzoOHWtAOtExB13Zt5Sw8kjQtWTECyuVdLVQhHupmRbatXwPHc69U_LmwQYTIfyZfTQPyZz8vLk0lHKpuCrswcwuU3xcu7wyY8jWDUP5XFxnQxuuFFV1LQpKZ9SmmHNy3ixTGCG9GErMxrqZrZti3WysG1Iyn97q1-3oun-Jv5oLwGYgl9XUu2Tu4zpNRc9_Wz_PIQ_RQJ9CNre_GKGSlNPUWvPfEKaUZQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1738818445</pqid></control><display><type>article</type><title>Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava</title><source>Springer Link</source><creator>Hussain, Hidayat ; Raees, Muhammad Adil ; Rehman, Najeeb Ur ; Al-Rawahi, Ahmed ; Csuk, René ; Khan, Husain Yar ; Abbas, Ghulam ; Al-Broumi, Mohammed Abdullah ; Green, Ivan R ; Elyassi, Ali ; Mahmood, Talat ; Al-Harrasi, Ahmed</creator><creatorcontrib>Hussain, Hidayat ; Raees, Muhammad Adil ; Rehman, Najeeb Ur ; Al-Rawahi, Ahmed ; Csuk, René ; Khan, Husain Yar ; Abbas, Ghulam ; Al-Broumi, Mohammed Abdullah ; Green, Ivan R ; Elyassi, Ali ; Mahmood, Talat ; Al-Harrasi, Ahmed</creatorcontrib><description>The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC₅₀ of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition.</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><identifier>DOI: 10.1007/s12272-015-0653-0</identifier><identifier>PMID: 26335549</identifier><language>eng</language><publisher>Seoul: Pharmaceutical Society of Korea</publisher><subject>acetylcholinesterase ; alpha-glucosidase ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; antioxidant activity ; antioxidants ; Apocynaceae ; breast neoplasms ; Cell Line, Tumor ; cell proliferation ; Cell Survival - drug effects ; Cell Survival - physiology ; Dose-Response Relationship, Drug ; doxorubicin ; enzyme inhibition ; Female ; glycosides ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Humans ; inhibition ; inhibitory concentration 50 ; mass spectrometry ; Medicine ; neoplasm cells ; nuclear magnetic resonance spectroscopy ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Pregnanes - chemistry ; Pregnanes - isolation & purification ; Pregnanes - pharmacology ; Research Article ; sap ; urease ; 약학</subject><ispartof>Archives of Pharmacal Research, 2015, 38(12), , pp.2137-2142</ispartof><rights>The Pharmaceutical Society of Korea 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3</citedby><cites>FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26335549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002056587$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussain, Hidayat</creatorcontrib><creatorcontrib>Raees, Muhammad Adil</creatorcontrib><creatorcontrib>Rehman, Najeeb Ur</creatorcontrib><creatorcontrib>Al-Rawahi, Ahmed</creatorcontrib><creatorcontrib>Csuk, René</creatorcontrib><creatorcontrib>Khan, Husain Yar</creatorcontrib><creatorcontrib>Abbas, Ghulam</creatorcontrib><creatorcontrib>Al-Broumi, Mohammed Abdullah</creatorcontrib><creatorcontrib>Green, Ivan R</creatorcontrib><creatorcontrib>Elyassi, Ali</creatorcontrib><creatorcontrib>Mahmood, Talat</creatorcontrib><creatorcontrib>Al-Harrasi, Ahmed</creatorcontrib><title>Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava</title><title>Archives of pharmacal research</title><addtitle>Arch. Pharm. Res</addtitle><addtitle>Arch Pharm Res</addtitle><description>The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC₅₀ of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition.</description><subject>acetylcholinesterase</subject><subject>alpha-glucosidase</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>antioxidant activity</subject><subject>antioxidants</subject><subject>Apocynaceae</subject><subject>breast neoplasms</subject><subject>Cell Line, Tumor</subject><subject>cell proliferation</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>doxorubicin</subject><subject>enzyme inhibition</subject><subject>Female</subject><subject>glycosides</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Humans</subject><subject>inhibition</subject><subject>inhibitory concentration 50</subject><subject>mass spectrometry</subject><subject>Medicine</subject><subject>neoplasm cells</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Pregnanes - chemistry</subject><subject>Pregnanes - isolation & purification</subject><subject>Pregnanes - pharmacology</subject><subject>Research Article</subject><subject>sap</subject><subject>urease</subject><subject>약학</subject><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PHSEUhompqVfbH-CmZamLUT4GBrozaquJqWmra3KGgRGdGa5wr0Z_fbkd22XZnITzvG_gQWifkiNKSHOcKWMNqwgVFZGCV2QLLahuZMUbJd-hBWHlUjKpd9BuzveEcCmEeI92mORciFov0I_v4fUZcujcFwx4cs8YplWwMFmX8DK5foLJ4X54sXEDYZ_iiFd3DmdY4ujxmctj6GKydyFjP8ATfEDbHobsPr7NPXT79fzm9KK6uv52eXpyVVnB1ariUlvNODRtqzoOHWtAOtExB13Zt5Sw8kjQtWTECyuVdLVQhHupmRbatXwPHc69U_LmwQYTIfyZfTQPyZz8vLk0lHKpuCrswcwuU3xcu7wyY8jWDUP5XFxnQxuuFFV1LQpKZ9SmmHNy3ixTGCG9GErMxrqZrZti3WysG1Iyn97q1-3oun-Jv5oLwGYgl9XUu2Tu4zpNRc9_Wz_PIQ_RQJ9CNre_GKGSlNPUWvPfEKaUZQ</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Hussain, Hidayat</creator><creator>Raees, Muhammad Adil</creator><creator>Rehman, Najeeb Ur</creator><creator>Al-Rawahi, Ahmed</creator><creator>Csuk, René</creator><creator>Khan, Husain Yar</creator><creator>Abbas, Ghulam</creator><creator>Al-Broumi, Mohammed Abdullah</creator><creator>Green, Ivan R</creator><creator>Elyassi, Ali</creator><creator>Mahmood, Talat</creator><creator>Al-Harrasi, Ahmed</creator><general>Pharmaceutical Society of Korea</general><general>대한약학회</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ACYCR</scope></search><sort><creationdate>20151201</creationdate><title>Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava</title><author>Hussain, Hidayat ; Raees, Muhammad Adil ; Rehman, Najeeb Ur ; Al-Rawahi, Ahmed ; Csuk, René ; Khan, Husain Yar ; Abbas, Ghulam ; Al-Broumi, Mohammed Abdullah ; Green, Ivan R ; Elyassi, Ali ; Mahmood, Talat ; Al-Harrasi, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>acetylcholinesterase</topic><topic>alpha-glucosidase</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>antioxidant activity</topic><topic>antioxidants</topic><topic>Apocynaceae</topic><topic>breast neoplasms</topic><topic>Cell Line, Tumor</topic><topic>cell proliferation</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>doxorubicin</topic><topic>enzyme inhibition</topic><topic>Female</topic><topic>glycosides</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Humans</topic><topic>inhibition</topic><topic>inhibitory concentration 50</topic><topic>mass spectrometry</topic><topic>Medicine</topic><topic>neoplasm cells</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Pregnanes - chemistry</topic><topic>Pregnanes - isolation & purification</topic><topic>Pregnanes - pharmacology</topic><topic>Research Article</topic><topic>sap</topic><topic>urease</topic><topic>약학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussain, Hidayat</creatorcontrib><creatorcontrib>Raees, Muhammad Adil</creatorcontrib><creatorcontrib>Rehman, Najeeb Ur</creatorcontrib><creatorcontrib>Al-Rawahi, Ahmed</creatorcontrib><creatorcontrib>Csuk, René</creatorcontrib><creatorcontrib>Khan, Husain Yar</creatorcontrib><creatorcontrib>Abbas, Ghulam</creatorcontrib><creatorcontrib>Al-Broumi, Mohammed Abdullah</creatorcontrib><creatorcontrib>Green, Ivan R</creatorcontrib><creatorcontrib>Elyassi, Ali</creatorcontrib><creatorcontrib>Mahmood, Talat</creatorcontrib><creatorcontrib>Al-Harrasi, Ahmed</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Korean Citation Index</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussain, Hidayat</au><au>Raees, Muhammad Adil</au><au>Rehman, Najeeb Ur</au><au>Al-Rawahi, Ahmed</au><au>Csuk, René</au><au>Khan, Husain Yar</au><au>Abbas, Ghulam</au><au>Al-Broumi, Mohammed Abdullah</au><au>Green, Ivan R</au><au>Elyassi, Ali</au><au>Mahmood, Talat</au><au>Al-Harrasi, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava</atitle><jtitle>Archives of pharmacal research</jtitle><stitle>Arch. Pharm. Res</stitle><addtitle>Arch Pharm Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>38</volume><issue>12</issue><spage>2137</spage><epage>2142</epage><pages>2137-2142</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC₅₀ of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition.</abstract><cop>Seoul</cop><pub>Pharmaceutical Society of Korea</pub><pmid>26335549</pmid><doi>10.1007/s12272-015-0653-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0253-6269 |
| ispartof | Archives of Pharmacal Research, 2015, 38(12), , pp.2137-2142 |
| issn | 0253-6269 1976-3786 |
| language | eng |
| recordid | cdi_nrf_kci_oai_kci_go_kr_ARTI_1136838 |
| source | Springer Link |
| subjects | acetylcholinesterase alpha-glucosidase Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology antioxidant activity antioxidants Apocynaceae breast neoplasms Cell Line, Tumor cell proliferation Cell Survival - drug effects Cell Survival - physiology Dose-Response Relationship, Drug doxorubicin enzyme inhibition Female glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans inhibition inhibitory concentration 50 mass spectrometry Medicine neoplasm cells nuclear magnetic resonance spectroscopy Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Pregnanes - chemistry Pregnanes - isolation & purification Pregnanes - pharmacology Research Article sap urease 약학 |
| title | Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A20%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nizwaside:%20a%20new%20anticancer%20pregnane%20glycoside%20from%20the%20sap%20of%20Desmidorchis%20flava&rft.jtitle=Archives%20of%20pharmacal%20research&rft.au=Hussain,%20Hidayat&rft.date=2015-12-01&rft.volume=38&rft.issue=12&rft.spage=2137&rft.epage=2142&rft.pages=2137-2142&rft.issn=0253-6269&rft.eissn=1976-3786&rft_id=info:doi/10.1007/s12272-015-0653-0&rft_dat=%3Cproquest_nrf_k%3E1738818445%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c538t-369c923a7bb8d3ad27a6e5d2ead538b102263a94620f5c686e45803f692959eb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1738818445&rft_id=info:pmid/26335549&rfr_iscdi=true |