Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt’s lymphoma cells

Natural killer (NK) cells are capable of identifying and killing tumor cells as well as virus infected cells without pre-sensitization. NK cells express activating and inhibitory receptors, and can distinguish between normal and tumor cells. The present study was designed to demonstrate the importan...

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Bibliographic Details
Published in:Archives of pharmacal research 2015, 38(11), , pp.2042-2048
Main Authors: Kim, Jeong Hwa, Lee, Jae Kwon
Format: Article
Language:English
Subjects:
antineoplastic agents
Antineoplastic Agents - pharmacology
Burkitt Lymphoma - drug therapy
Burkitt Lymphoma - immunology
Cell Line, Tumor
Flavanones - pharmacology
hesperetin
Humans
immunotherapy
kaempferol
Killer Cells, Natural - immunology
ligands
luteolin
Medicine
naringenin
natural killer cells
neoplasm cells
NK Cell Lectin-Like Receptor Subfamily K - immunology
Pharmacology/Toxicology
Pharmacy
pretreatment
receptors
Research Article
taxifolin
viruses
약학
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Summary:Natural killer (NK) cells are capable of identifying and killing tumor cells as well as virus infected cells without pre-sensitization. NK cells express activating and inhibitory receptors, and can distinguish between normal and tumor cells. The present study was designed to demonstrate the importance of the expression level of NKG2D ligands on the Burkitt’s lymphoma cell line, Raji, in enhancing NK cell cytolytic activity. Various flavonoids were used as stimulants to enhance the expression of NKG2D ligands. NK cell lysis activity against Raji was not changed by pre-treatment of Raji with luteolin, kaempferol, taxifolin and hesperetin. However, treatment of Raji with naringenin showed increased sensitivity to NK cell lysis than untreated control cells. The activity of naringenin was due to enhanced NKG2D ligand expression. These results provide evidence that narigenin’s antitumor activity may be due to targeting of NKG2D ligand expression and suggests a possible immunotherapeutic role for cancer treatment.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-015-0624-5