Chemical constituents from Belamcanda chinensis and their inhibitory effects on nitric oxide production in RAW 264.7 macrophage cells

Belamcanda chinensis (L.) DC., which belongs to the family of Iridaceae, has been used as a folk medicine for the treatment of inflammation, asthma, tonsillitis, and many other throat disorders. Bioactivity-guided purification of the methylene chloride-soluble fraction of the rhizomes of B. chinensi...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2015, 38(6), , pp.991-997
Main Authors: Lee, Jin Woo, Lee, Chul, Jin, Qinghao, Lee, Moon-Soon, Kim, Youngsoo, Hong, Jin Tae, Lee, Mi Kyeong, Hwang, Bang Yeon
Format: Article
Language:English
Subjects:
Animals
asthma
Belamcanda chinensis
Cell Survival - drug effects
chemical composition
electrospray ionization mass spectrometry
inflammation
Iridaceae - chemistry
Isoflavones - pharmacology
macrophages
Macrophages - drug effects
Macrophages - metabolism
Magnetic Resonance Spectroscopy
Medicine
Mice
nitric oxide
Nitric Oxide - biosynthesis
nuclear magnetic resonance spectroscopy
Pharmacology/Toxicology
Pharmacy
Plant Extracts - chemistry
RAW 264.7 Cells
Research Article
Rhizome - chemistry
rhizomes
spectral analysis
Spectrometry, Mass, Electrospray Ionization
throat
traditional medicine
약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Belamcanda chinensis (L.) DC., which belongs to the family of Iridaceae, has been used as a folk medicine for the treatment of inflammation, asthma, tonsillitis, and many other throat disorders. Bioactivity-guided purification of the methylene chloride-soluble fraction of the rhizomes of B. chinensis based on the inhibition of nitric oxide production led to the identification of seventeen known compounds. Their structures were elucidated on the basis of extensive spectroscopic measurement such as NMR and ESI–MS. All of the isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophage cells.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-014-0529-8